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Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children

BACKGROUND: Priming for cardiometabolic diseases, including non-alcoholic fatty liver disease (NAFLD), is hypothesized to begin in utero. The primary objective of this study is to determine whether there is an association between maternal nutritional status and offspring NAFLD. METHODS: Data come fr...

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Autores principales: Sekkarie, Ahlia, Welsh, Jean A., Northstone, Kate, Stein, Aryeh D., Ramakrishnan, Usha, Vos, Miriam B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265091/
https://www.ncbi.nlm.nih.gov/pubmed/34233762
http://dx.doi.org/10.1186/s40795-021-00433-3
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author Sekkarie, Ahlia
Welsh, Jean A.
Northstone, Kate
Stein, Aryeh D.
Ramakrishnan, Usha
Vos, Miriam B.
author_facet Sekkarie, Ahlia
Welsh, Jean A.
Northstone, Kate
Stein, Aryeh D.
Ramakrishnan, Usha
Vos, Miriam B.
author_sort Sekkarie, Ahlia
collection PubMed
description BACKGROUND: Priming for cardiometabolic diseases, including non-alcoholic fatty liver disease (NAFLD), is hypothesized to begin in utero. The primary objective of this study is to determine whether there is an association between maternal nutritional status and offspring NAFLD. METHODS: Data come from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK. The analytic sample included 3353 participants who had maternal information on pre-pregnancy BMI, gestational weight gain, diabetes, and free sugar intake as percent of total energy and were assessed for mild-severe hepatic steatosis at 24 years by transient elastography (controlled attenuation parameter score ≥ 248 dB/m). Multiple logistic regression was used to evaluate the association between maternal factors and offspring hepatic steatosis at 24 years. RESULTS: In confounder-adjusted models the independent associations for each maternal factor with mild to severe vs low hepatic steatosis at 24 years were: pre-pregnancy overweight (OR: 1.84, 95%CL: 1.43–2.38) or obesity (OR: 2.73, 95%CL: 1.84–4.03), more than recommended gestational weight gain (OR: 1.30, 95%CL: 1.04–1.64), diabetes (OR: 1.39, 95%CI: 0.87, 2.21), and high free sugar intake during pregnancy (OR: 1.04, 95% CI: 0.82, 1.33). These associations were largely mediated by BMI at 24 years, but not by birthweight or breastfeeding. CONCLUSIONS: Our results suggest that maternal nutritional status is associated with the development of NAFLD in their adult offspring, although the relationship is largely mediated by offspring BMI in adulthood. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-021-00433-3.
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spelling pubmed-82650912021-07-08 Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children Sekkarie, Ahlia Welsh, Jean A. Northstone, Kate Stein, Aryeh D. Ramakrishnan, Usha Vos, Miriam B. BMC Nutr Research BACKGROUND: Priming for cardiometabolic diseases, including non-alcoholic fatty liver disease (NAFLD), is hypothesized to begin in utero. The primary objective of this study is to determine whether there is an association between maternal nutritional status and offspring NAFLD. METHODS: Data come from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK. The analytic sample included 3353 participants who had maternal information on pre-pregnancy BMI, gestational weight gain, diabetes, and free sugar intake as percent of total energy and were assessed for mild-severe hepatic steatosis at 24 years by transient elastography (controlled attenuation parameter score ≥ 248 dB/m). Multiple logistic regression was used to evaluate the association between maternal factors and offspring hepatic steatosis at 24 years. RESULTS: In confounder-adjusted models the independent associations for each maternal factor with mild to severe vs low hepatic steatosis at 24 years were: pre-pregnancy overweight (OR: 1.84, 95%CL: 1.43–2.38) or obesity (OR: 2.73, 95%CL: 1.84–4.03), more than recommended gestational weight gain (OR: 1.30, 95%CL: 1.04–1.64), diabetes (OR: 1.39, 95%CI: 0.87, 2.21), and high free sugar intake during pregnancy (OR: 1.04, 95% CI: 0.82, 1.33). These associations were largely mediated by BMI at 24 years, but not by birthweight or breastfeeding. CONCLUSIONS: Our results suggest that maternal nutritional status is associated with the development of NAFLD in their adult offspring, although the relationship is largely mediated by offspring BMI in adulthood. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40795-021-00433-3. BioMed Central 2021-07-08 /pmc/articles/PMC8265091/ /pubmed/34233762 http://dx.doi.org/10.1186/s40795-021-00433-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Sekkarie, Ahlia
Welsh, Jean A.
Northstone, Kate
Stein, Aryeh D.
Ramakrishnan, Usha
Vos, Miriam B.
Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title_full Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title_fullStr Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title_full_unstemmed Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title_short Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children
title_sort associations of maternal diet and nutritional status with offspring hepatic steatosis in the avon longitudinal study of parents and children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265091/
https://www.ncbi.nlm.nih.gov/pubmed/34233762
http://dx.doi.org/10.1186/s40795-021-00433-3
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