TISIGNER.com: web services for improving recombinant protein production

Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein production. We offer three web services, TIsigner (Tran...

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Detalles Bibliográficos
Autores principales: Bhandari, Bikash K, Lim, Chun Shen, Gardner, Paul P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Web Server Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265118/
https://www.ncbi.nlm.nih.gov/pubmed/33744969
http://dx.doi.org/10.1093/nar/gkab175
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author Bhandari, Bikash K
Lim, Chun Shen
Gardner, Paul P
author_facet Bhandari, Bikash K
Lim, Chun Shen
Gardner, Paul P
author_sort Bhandari, Bikash K
collection PubMed
description Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein production. We offer three web services, TIsigner (Translation Initiation coding region designer), SoDoPE (Soluble Domain for Protein Expression) and Razor, which are specialised in synonymous optimisation of recombinant protein expression, solubility and signal peptide analysis, respectively. Importantly, TIsigner, SoDoPE and Razor are linked, which allows users to switch between the tools when optimising genes of interest.
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spelling pubmed-82651182021-07-09 TISIGNER.com: web services for improving recombinant protein production Bhandari, Bikash K Lim, Chun Shen Gardner, Paul P Nucleic Acids Res Web Server Issue Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein production. We offer three web services, TIsigner (Translation Initiation coding region designer), SoDoPE (Soluble Domain for Protein Expression) and Razor, which are specialised in synonymous optimisation of recombinant protein expression, solubility and signal peptide analysis, respectively. Importantly, TIsigner, SoDoPE and Razor are linked, which allows users to switch between the tools when optimising genes of interest. Oxford University Press 2021-03-21 /pmc/articles/PMC8265118/ /pubmed/33744969 http://dx.doi.org/10.1093/nar/gkab175 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Web Server Issue
Bhandari, Bikash K
Lim, Chun Shen
Gardner, Paul P
TISIGNER.com: web services for improving recombinant protein production
title TISIGNER.com: web services for improving recombinant protein production
title_full TISIGNER.com: web services for improving recombinant protein production
title_fullStr TISIGNER.com: web services for improving recombinant protein production
title_full_unstemmed TISIGNER.com: web services for improving recombinant protein production
title_short TISIGNER.com: web services for improving recombinant protein production
title_sort tisigner.com: web services for improving recombinant protein production
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265118/
https://www.ncbi.nlm.nih.gov/pubmed/33744969
http://dx.doi.org/10.1093/nar/gkab175
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