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Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

BACKGROUND: Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke. METHODS: We ap...

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Detalles Bibliográficos
Autores principales: Yin, Junjun, Wan, Jiayang, Zhu, Jiaqi, Zhou, Guoying, Pan, Yuming, Zhou, Huifen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265129/
https://www.ncbi.nlm.nih.gov/pubmed/34233704
http://dx.doi.org/10.1186/s13020-021-00464-9
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author Yin, Junjun
Wan, Jiayang
Zhu, Jiaqi
Zhou, Guoying
Pan, Yuming
Zhou, Huifen
author_facet Yin, Junjun
Wan, Jiayang
Zhu, Jiaqi
Zhou, Guoying
Pan, Yuming
Zhou, Huifen
author_sort Yin, Junjun
collection PubMed
description BACKGROUND: Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke. METHODS: We applied bibliometric methods and techniques. The Web of Science Core Collection was searched for studies indexed from database inception to November 26, 2020. We generated various visual maps to display publications, authors, sources, countries, and keywords. RESULTS: Our literature search yielded 427 publications related to inflammasomes involved in stroke, most of which consisted of original research articles and reviews. In particular, we found that there was a substantial increase in the number of relevant publications in 2018. Furthermore, most of the publications with the highest citation rates were published in 2014. Relatively, the field about inflammasomes in stroke developed rapidly in 2014 and 2018. Many institutions contributed to these publications, including those from China, the United States, and worldwide. We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca(2+) ions, dysfunction of K(+)/Na(+) ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA. CONCLUSIONS: Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We used bibliometric methods to objectively present the global trend of inflammasomes in stroke, and to provide important information for relevant researchers.
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spelling pubmed-82651292021-07-08 Global trends and prospects about inflammasomes in stroke: a bibliometric analysis Yin, Junjun Wan, Jiayang Zhu, Jiaqi Zhou, Guoying Pan, Yuming Zhou, Huifen Chin Med Review BACKGROUND: Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke. METHODS: We applied bibliometric methods and techniques. The Web of Science Core Collection was searched for studies indexed from database inception to November 26, 2020. We generated various visual maps to display publications, authors, sources, countries, and keywords. RESULTS: Our literature search yielded 427 publications related to inflammasomes involved in stroke, most of which consisted of original research articles and reviews. In particular, we found that there was a substantial increase in the number of relevant publications in 2018. Furthermore, most of the publications with the highest citation rates were published in 2014. Relatively, the field about inflammasomes in stroke developed rapidly in 2014 and 2018. Many institutions contributed to these publications, including those from China, the United States, and worldwide. We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca(2+) ions, dysfunction of K(+)/Na(+) ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA. CONCLUSIONS: Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We used bibliometric methods to objectively present the global trend of inflammasomes in stroke, and to provide important information for relevant researchers. BioMed Central 2021-07-07 /pmc/articles/PMC8265129/ /pubmed/34233704 http://dx.doi.org/10.1186/s13020-021-00464-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yin, Junjun
Wan, Jiayang
Zhu, Jiaqi
Zhou, Guoying
Pan, Yuming
Zhou, Huifen
Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title_full Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title_fullStr Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title_full_unstemmed Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title_short Global trends and prospects about inflammasomes in stroke: a bibliometric analysis
title_sort global trends and prospects about inflammasomes in stroke: a bibliometric analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265129/
https://www.ncbi.nlm.nih.gov/pubmed/34233704
http://dx.doi.org/10.1186/s13020-021-00464-9
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