Cargando…

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

BACKGROUND: Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different species are not clear. This study aims to explore the effects of leptin in mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Yi, Haks, Mariëlle C., Forn-Cuní, Gabriel, He, Junling, Nowik, Natalia, Harms, Amy C., Hankemeier, Thomas, Eeza, Muhamed N. H., Matysik, Jörg, Alia, A., Spaink, Herman P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265131/ https://www.ncbi.nlm.nih.gov/pubmed/34233759 http://dx.doi.org/10.1186/s13578-021-00642-0

Ejemplares similares

Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome
por: Ding, Yi, et al.
Publicado: (2022)

Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging
por: Eeza, Muhamed N. Hashem, et al.
Publicado: (2023)

Transcriptomic and Metabolomic Studies Reveal That Toll-like Receptor 2 Has a Role in Glucose-Related Metabolism in Unchallenged Zebrafish Larvae (Danio rerio)
por: Hu, Wanbin, et al.
Publicado: (2023)

The Role of Galanin during Bacterial Infection in Larval Zebrafish
por: Nowik, Natalia, et al.
Publicado: (2021)

NMR-Based Metabolic Profiles of Intact Zebrafish Embryos Exposed to Aflatoxin B1 Recapitulates Hepatotoxicity and Supports Possible Neurotoxicity
por: Zuberi, Zain, et al.
Publicado: (2019)

An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling
por: Eeza, Muhamed N. H., et al.
Publicado: (2022)

Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae
por: Ding, Yi, et al.
Publicado: (2020)

Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models
por: Saxena, Saloni, et al.
Publicado: (2021)

Zebrafish in Inflammasome Research
por: Forn-Cuní, Gabriel, et al.
Publicado: (2019)

High-Resolution Magic Angle Spinning (HRMAS) NMR Identifies Oxidative Stress and Impairment of Energy Metabolism by Zearalenone in Embryonic Stages of Zebrafish (Danio rerio), Olive Flounder (Paralichthys olivaceus) and Yellowtail Snapper (Ocyurus chrysurus)
por: Annunziato, Mark, et al.
Publicado: (2023)

Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics
por: Vrieling, Frank, et al.
Publicado: (2020)

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae
por: van Wijk, Rob C., et al.
Publicado: (2019)

Specificity of the innate immune responses to different classes of non-tuberculous mycobacteria
por: Hu, Wanbin, et al.
Publicado: (2023)

Conserved gene regulation during acute inflammation between zebrafish and mammals
por: Forn-Cuní, G., et al.
Publicado: (2017)

XePhIR: the zebrafish xenograft phenotype interactive repository
por: Groenewoud, A, et al.
Publicado: (2022)

Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer’s Disease Mouse Model
por: Eeza, Muhamed N.H., et al.
Publicado: (2021)

smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish
por: Castillo-Robles, Jorge, et al.
Publicado: (2018)

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude
por: Kantae, Vasudev, et al.
Publicado: (2016)

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish
por: Moreira, Jôsimar D., et al.
Publicado: (2020)

Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system
por: van der Vaart, Michiel, et al.
Publicado: (2013)

Imaging epilepsy in larval zebrafish
por: Burrows, D.R.W., et al.
Publicado: (2020)

The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection
por: Zhang, Rui, et al.
Publicado: (2019)

Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish
por: Mancienne, Tessa, et al.
Publicado: (2021)

Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit
por: Pérez-Rius, Carla, et al.
Publicado: (2019)

Host-Pathogen Interactions Made Transparent with the Zebrafish Model
por: Meijer, Annemarie H, et al.
Publicado: (2011)

Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis
por: Forn-Cuní, G, et al.
Publicado: (2022)

Fast, easy and early (larval) identification of transparent mutant zebrafish using standard fluorescence microscopy
por: Wenz, Ralf, et al.
Publicado: (2020)

Assessment of Autism Zebrafish Mutant Models Using a High-Throughput Larval Phenotyping Platform
por: Colón-Rodríguez, Alexandra, et al.
Publicado: (2020)

Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine
por: Webb, Katharine J, et al.
Publicado: (2009)

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis
por: Boland, Ralf, et al.
Publicado: (2022)

Hypothalamic Projections to the Optic Tectum in Larval Zebrafish
por: Heap, Lucy A., et al.
Publicado: (2018)

Adaptive Locomotor Behavior in Larval Zebrafish
por: Portugues, Ruben, et al.
Publicado: (2011)

Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish
por: Zheng, Chuanrui, et al.
Publicado: (2020)

Status of Metabolomic Measurement for Insights in Alzheimer’s Disease Progression—What Is Missing?
por: Yin, Chunyuan, et al.
Publicado: (2023)

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish
por: van der Vaart, Michiel, et al.
Publicado: (2012)

Systematic Evaluation of HILIC Stationary Phases for Global Metabolomics of Human Plasma
por: Hosseinkhani, Farideh, et al.
Publicado: (2022)

Genome Sequence of Aeromonas hydrophila Strain AH-3 (Serotype O34)
por: Forn-Cuní, Gabriel, et al.
Publicado: (2016)

Whole-Genome Sequence of Aeromonas hydrophila Strain AH-1 (Serotype O11)
por: Forn-Cuní, Gabriel, et al.
Publicado: (2016)

Comparative Genomics of the Aeromonadaceae Core Oligosaccharide Biosynthetic Regions
por: Forn-Cuní, Gabriel, et al.
Publicado: (2017)

A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
por: Bashirova, Narmin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4ath3mm8ddbkqqbkelbs0l807k