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Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival

BACKGROUND: Plasma cell neoplasms can show aberrant expression of different lineage-related antigens; however, co-expression of T-cell-associated markers on malignant plasma cells is extremely rare. MATERIAL AND METHODS: This report describes clinicopathologic characteristics of three myeloma patien...

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Autores principales: Soliman, Dina Sameh A., El Sabah, Hesham, Ganwo, Ibrahim, Amer, Aliaa, Taha, Ruba Y., Szabados, Lajos, Eldean, Mouhammad Sharaf, Al-Sabbagh, Ahmad, Ibrahim, Feryal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265333/
https://www.ncbi.nlm.nih.gov/pubmed/34276912
http://dx.doi.org/10.4084/MJHID.2021.043
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author Soliman, Dina Sameh A.
El Sabah, Hesham
Ganwo, Ibrahim
Amer, Aliaa
Taha, Ruba Y.
Szabados, Lajos
Eldean, Mouhammad Sharaf
Al-Sabbagh, Ahmad
Ibrahim, Feryal
author_facet Soliman, Dina Sameh A.
El Sabah, Hesham
Ganwo, Ibrahim
Amer, Aliaa
Taha, Ruba Y.
Szabados, Lajos
Eldean, Mouhammad Sharaf
Al-Sabbagh, Ahmad
Ibrahim, Feryal
author_sort Soliman, Dina Sameh A.
collection PubMed
description BACKGROUND: Plasma cell neoplasms can show aberrant expression of different lineage-related antigens; however, co-expression of T-cell-associated markers on malignant plasma cells is extremely rare. MATERIAL AND METHODS: This report describes clinicopathologic characteristics of three myeloma patients with emergent plasmablastic morphology and aberrant acquisition of T-cell-associated markers diagnosed in our center. An extensive literature search for similar cases was conducted, and the relevant pathologic, clinical, and prognostic characteristics were summarized. RESULTS: A total of 22 cases of plasma cell neoplasm (including the three cases reported here) showed aberrant co-expression of T-cell markers. We found an evident association between aberrant expression of T-cell markers on malignant plasma cells and extramedullary involvement, aggressive morphologic features, high proliferative index ki67 >90%, aggressive clinical course, an adverse outcome, and short survival. DISCUSSION & CONCLUSION: Due to the rarity of this aberrant phenotype and scarcity of the published data, the precise causative mechanism and its clinical implications have not yet been elucidated.
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spelling pubmed-82653332021-07-16 Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival Soliman, Dina Sameh A. El Sabah, Hesham Ganwo, Ibrahim Amer, Aliaa Taha, Ruba Y. Szabados, Lajos Eldean, Mouhammad Sharaf Al-Sabbagh, Ahmad Ibrahim, Feryal Mediterr J Hematol Infect Dis Case Report BACKGROUND: Plasma cell neoplasms can show aberrant expression of different lineage-related antigens; however, co-expression of T-cell-associated markers on malignant plasma cells is extremely rare. MATERIAL AND METHODS: This report describes clinicopathologic characteristics of three myeloma patients with emergent plasmablastic morphology and aberrant acquisition of T-cell-associated markers diagnosed in our center. An extensive literature search for similar cases was conducted, and the relevant pathologic, clinical, and prognostic characteristics were summarized. RESULTS: A total of 22 cases of plasma cell neoplasm (including the three cases reported here) showed aberrant co-expression of T-cell markers. We found an evident association between aberrant expression of T-cell markers on malignant plasma cells and extramedullary involvement, aggressive morphologic features, high proliferative index ki67 >90%, aggressive clinical course, an adverse outcome, and short survival. DISCUSSION & CONCLUSION: Due to the rarity of this aberrant phenotype and scarcity of the published data, the precise causative mechanism and its clinical implications have not yet been elucidated. Università Cattolica del Sacro Cuore 2021-07-01 /pmc/articles/PMC8265333/ /pubmed/34276912 http://dx.doi.org/10.4084/MJHID.2021.043 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Soliman, Dina Sameh A.
El Sabah, Hesham
Ganwo, Ibrahim
Amer, Aliaa
Taha, Ruba Y.
Szabados, Lajos
Eldean, Mouhammad Sharaf
Al-Sabbagh, Ahmad
Ibrahim, Feryal
Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title_full Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title_fullStr Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title_full_unstemmed Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title_short Aberrant Acquisition of T-cell Associated Markers in Plasma Cell Neoplasms: An Aggressive Disease with Extramedullary Involvement and Very Short Survival
title_sort aberrant acquisition of t-cell associated markers in plasma cell neoplasms: an aggressive disease with extramedullary involvement and very short survival
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265333/
https://www.ncbi.nlm.nih.gov/pubmed/34276912
http://dx.doi.org/10.4084/MJHID.2021.043
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