Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis

Amphotericin B (AmB) is a polyene antifungal agent used widely for systemic fungal infections. Infusion-related side effects, nephrotoxicity, and dyselectrolytemia are well-known adverse effects with the use of this drug. Liposomal preparation of AmB has less adverse events. However, ototoxicity due...

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Autores principales: Ramu, Ramadoss, Sharma, Brijesh, Karunakara, Dheeresh, Paliwal, Purnima, Bansal, Naman, Taneja, Rajesh Satyapal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265420/
https://www.ncbi.nlm.nih.gov/pubmed/34100400
http://dx.doi.org/10.4103/0253-7613.316948
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author Ramu, Ramadoss
Sharma, Brijesh
Karunakara, Dheeresh
Paliwal, Purnima
Bansal, Naman
Taneja, Rajesh Satyapal
author_facet Ramu, Ramadoss
Sharma, Brijesh
Karunakara, Dheeresh
Paliwal, Purnima
Bansal, Naman
Taneja, Rajesh Satyapal
author_sort Ramu, Ramadoss
collection PubMed
description Amphotericin B (AmB) is a polyene antifungal agent used widely for systemic fungal infections. Infusion-related side effects, nephrotoxicity, and dyselectrolytemia are well-known adverse effects with the use of this drug. Liposomal preparation of AmB has less adverse events. However, ototoxicity due to AmB is scarcely mentioned in the literature. We report a case of disseminated histoplasmosis who was treated with liposomal amphotericin B (LAmB) and developed hearing loss during the treatment, which recovered after discontinuing the drug. This is a rare adverse effect of LAmB and reported only once from India, to the best of our knowledge.
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spelling pubmed-82654202021-07-16 Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis Ramu, Ramadoss Sharma, Brijesh Karunakara, Dheeresh Paliwal, Purnima Bansal, Naman Taneja, Rajesh Satyapal Indian J Pharmacol Drug Watch Amphotericin B (AmB) is a polyene antifungal agent used widely for systemic fungal infections. Infusion-related side effects, nephrotoxicity, and dyselectrolytemia are well-known adverse effects with the use of this drug. Liposomal preparation of AmB has less adverse events. However, ototoxicity due to AmB is scarcely mentioned in the literature. We report a case of disseminated histoplasmosis who was treated with liposomal amphotericin B (LAmB) and developed hearing loss during the treatment, which recovered after discontinuing the drug. This is a rare adverse effect of LAmB and reported only once from India, to the best of our knowledge. Wolters Kluwer - Medknow 2021 2021-05-26 /pmc/articles/PMC8265420/ /pubmed/34100400 http://dx.doi.org/10.4103/0253-7613.316948 Text en Copyright: © 2021 Indian Journal of Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Drug Watch
Ramu, Ramadoss
Sharma, Brijesh
Karunakara, Dheeresh
Paliwal, Purnima
Bansal, Naman
Taneja, Rajesh Satyapal
Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title_full Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title_fullStr Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title_full_unstemmed Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title_short Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis
title_sort liposomal amphotericin b-induced reversible ototoxicity in a patient with disseminated histoplasmosis
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265420/
https://www.ncbi.nlm.nih.gov/pubmed/34100400
http://dx.doi.org/10.4103/0253-7613.316948
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