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Effects of Natalizumab Therapy on Intrathecal Immunoglobulin G Production Indicate Targeting of Plasmablasts

OBJECTIVES: To evaluate the long-term effects of natalizumab (NTZ) on different features of intrathecal immunoglobulin (Ig) synthesis in patients with multiple sclerosis (MS) and to quantify the expression of α4-integrin in stages of B-cell maturation. METHODS: We combined a cross-sectional (49 NTZ-...

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Detalles Bibliográficos
Autores principales:	Schlüter, Miriam, Oswald, Eva, Winklmeier, Stephan, Meinl, Ingrid, Havla, Joachim, Eichhorn, Peter, Meinl, Edgar, Kümpfel, Tania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265584/ https://www.ncbi.nlm.nih.gov/pubmed/34210800 http://dx.doi.org/10.1212/NXI.0000000000001030

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