Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator

Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABA(A) receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABA(A) receptor current at nine unique human recombinant receptor s...

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Detalles Bibliográficos
Autores principales: Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265595/
https://www.ncbi.nlm.nih.gov/pubmed/32976892
http://dx.doi.org/10.1016/j.neuropharm.2020.108333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265595/
https://www.ncbi.nlm.nih.gov/pubmed/32976892
http://dx.doi.org/10.1016/j.neuropharm.2020.108333

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