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Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report

BACKGROUND: Myotonic dystrophy (dystrophia myotonica [DM]) is an autosomal-dominant inheritance, and myasthenia gravis (MG) is an autoimmune disease characterized by weakness of skeletal muscles. Cases of both DM and MG are extremely rare and distinguishing DM and MG symptoms is challenging. CASE PR...

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Autores principales: Miyawaki, Michiyo, Jikumaru, Mika, Kamada, Kosuke, Daiki, Noda, Abe, Miyuki, Anami, Kentaro, Takeuchi, Hideya, Osoegawa, Atsushi, Iwao, Sintaro, Matsubara, Etsuro, Sugio, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265721/
https://www.ncbi.nlm.nih.gov/pubmed/34240257
http://dx.doi.org/10.1186/s40792-021-01223-6
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author Miyawaki, Michiyo
Jikumaru, Mika
Kamada, Kosuke
Daiki, Noda
Abe, Miyuki
Anami, Kentaro
Takeuchi, Hideya
Osoegawa, Atsushi
Iwao, Sintaro
Matsubara, Etsuro
Sugio, Kenji
author_facet Miyawaki, Michiyo
Jikumaru, Mika
Kamada, Kosuke
Daiki, Noda
Abe, Miyuki
Anami, Kentaro
Takeuchi, Hideya
Osoegawa, Atsushi
Iwao, Sintaro
Matsubara, Etsuro
Sugio, Kenji
author_sort Miyawaki, Michiyo
collection PubMed
description BACKGROUND: Myotonic dystrophy (dystrophia myotonica [DM]) is an autosomal-dominant inheritance, and myasthenia gravis (MG) is an autoimmune disease characterized by weakness of skeletal muscles. Cases of both DM and MG are extremely rare and distinguishing DM and MG symptoms is challenging. CASE PRESENTATION: We herein report a 49-year-old woman presenting with subacute dyspnea and muscle weakness. She had previously been diagnosed with DM 24 years earlier. Computed tomography (CT) revealed an anterior mediastinal 32-mm solid mass that was suspected of being thymoma. The clinical features and neurological examination findings confirmed the diagnosis of thymoma-associated MG coexisting with DM. Intensive treatment for MG, including surgery, resulted in an improvement in some of her neurological symptoms. CONCLUSIONS: The symptoms of DM usually progress slowly, so the sudden exacerbation of symptoms indicates the involvement of other factors. It is important to be aware of these associations, as an early diagnosis with proper treatment will result in a better outcome.
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spelling pubmed-82657212021-07-09 Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report Miyawaki, Michiyo Jikumaru, Mika Kamada, Kosuke Daiki, Noda Abe, Miyuki Anami, Kentaro Takeuchi, Hideya Osoegawa, Atsushi Iwao, Sintaro Matsubara, Etsuro Sugio, Kenji Surg Case Rep Case Report BACKGROUND: Myotonic dystrophy (dystrophia myotonica [DM]) is an autosomal-dominant inheritance, and myasthenia gravis (MG) is an autoimmune disease characterized by weakness of skeletal muscles. Cases of both DM and MG are extremely rare and distinguishing DM and MG symptoms is challenging. CASE PRESENTATION: We herein report a 49-year-old woman presenting with subacute dyspnea and muscle weakness. She had previously been diagnosed with DM 24 years earlier. Computed tomography (CT) revealed an anterior mediastinal 32-mm solid mass that was suspected of being thymoma. The clinical features and neurological examination findings confirmed the diagnosis of thymoma-associated MG coexisting with DM. Intensive treatment for MG, including surgery, resulted in an improvement in some of her neurological symptoms. CONCLUSIONS: The symptoms of DM usually progress slowly, so the sudden exacerbation of symptoms indicates the involvement of other factors. It is important to be aware of these associations, as an early diagnosis with proper treatment will result in a better outcome. Springer Berlin Heidelberg 2021-07-08 /pmc/articles/PMC8265721/ /pubmed/34240257 http://dx.doi.org/10.1186/s40792-021-01223-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Miyawaki, Michiyo
Jikumaru, Mika
Kamada, Kosuke
Daiki, Noda
Abe, Miyuki
Anami, Kentaro
Takeuchi, Hideya
Osoegawa, Atsushi
Iwao, Sintaro
Matsubara, Etsuro
Sugio, Kenji
Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title_full Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title_fullStr Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title_full_unstemmed Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title_short Thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
title_sort thymoma-associated myasthenia gravis coexisting with myotonic dystrophy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265721/
https://www.ncbi.nlm.nih.gov/pubmed/34240257
http://dx.doi.org/10.1186/s40792-021-01223-6
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