Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

[Image: see text] The papain-like protease (PL(pro)) of SARS-CoV-2 is a validated antiviral drug target. Through a fluorescence resonance energy transfer-based high-throughput screening and subsequent lead optimization, we identified several PL(pro) inhibitors including Jun9-72-2 and Jun9-75-4 with...

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Detalles Bibliográficos
Autores principales: Ma, Chunlong, Sacco, Michael Dominic, Xia, Zilei, Lambrinidis, George, Townsend, Julia Alma, Hu, Yanmei, Meng, Xiangzhi, Szeto, Tommy, Ba, Mandy, Zhang, Xiujun, Gongora, Maura, Zhang, Fushun, Marty, Michael Thomas, Xiang, Yan, Kolocouris, Antonios, Chen, Yu, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265724/
https://www.ncbi.nlm.nih.gov/pubmed/34341772
http://dx.doi.org/10.1021/acscentsci.1c00519

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