Incidence of Insulin Resistance in Obese Adolescent of Type-2 Diabetes Mellitus Patients

Background: Insulin resistance is a reduced response of tissue to insulin-mediated action on cells. It may be due to many reasons, including the surplus of adipose tissue, which cause a resistance of insulin. Aims and Objectives: To find the incidence of insulin resistance in obese adolescent of type-2 diabetes mellitus patients. Material and Methods: The study involved 50 adolescents aged 14–20 years old. Adolescents with BMI > 26.0 Kg/m2 were included in the study. Levels of fasting blood sugar, Hb A1c and serum insulin were estimated. The index of Homeostatic model assessment for insulin resistance or HOMA-IR was calculated. The cut-off value of HOMA-IR was > 3.16 for both genders. Results: It was observed that the values of BMI and level of fasting blood sugar of first degree relatives of diabetics was significantly higher as compared to their controls. Levels of both blood HbA1c and serum insulin were increased but significant difference was observed only in case of serum insulin when compared with their controls. Conclusion: Obesity in adolescents of first degree relatives of diabetics shows a major reason of insulin resistance. The incidence of insulin resistance in obese adolescents signals a perturbing trend for the burden of type 2 diabetes in our country.