The Novel Oral BET-CBP/p300 Dual Inhibitor NEO2734 Is Highly Effective in Eradicating Acute Myeloid Leukemia Blasts and Stem/Progenitor Cells

Acute myeloid leukemia (AML) is a disease characterized by transcriptional dysregulation that results in a block in differentiation and aberrant self-renewal. Inhibitors directed to epigenetic modifiers, aiming at transcriptional reprogramming of AML cells, are currently in clinical trials for AML p...

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Detalles Bibliográficos
Autores principales: van Gils, Noortje, Martiañez Canales, Tania, Vermue, Eline, Rutten, Arjo, Denkers, Fedor, van der Deure, Tiem, Ossenkoppele, Gert J., Giles, Francis, Smit, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265862/
https://www.ncbi.nlm.nih.gov/pubmed/34258514
http://dx.doi.org/10.1097/HS9.0000000000000610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8265862/
https://www.ncbi.nlm.nih.gov/pubmed/34258514
http://dx.doi.org/10.1097/HS9.0000000000000610

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