Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms

The APOBEC3 (A3) genes encode cytidine deaminase proteins with potent antiviral and anti-retroelement activity. This locus is characterized by duplication, recombination, and deletion events that gave rise to the seven A3s found in primates. These include three single deaminase domain A3s (A3A, A3C,...

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Detalles Bibliográficos
Autores principales: McDonnell, Mollie M., Karvonen, Suzanne C., Gaba, Amit, Flath, Ben, Chelico, Linda, Emerman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266076/
https://www.ncbi.nlm.nih.gov/pubmed/34170969
http://dx.doi.org/10.1371/journal.ppat.1009523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266076/
https://www.ncbi.nlm.nih.gov/pubmed/34170969
http://dx.doi.org/10.1371/journal.ppat.1009523

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