Time to reconsider the role of ribavirin in Lassa fever

Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some Lassa fever patients. An urgent reevaluation o...

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Detalles Bibliográficos
Autores principales: Salam, Alex Paddy, Cheng, Vincent, Edwards, Tansy, Olliaro, Piero, Sterne, Jonathan, Horby, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Viewpoints
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266111/
https://www.ncbi.nlm.nih.gov/pubmed/34237063
http://dx.doi.org/10.1371/journal.pntd.0009522
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author Salam, Alex Paddy
Cheng, Vincent
Edwards, Tansy
Olliaro, Piero
Sterne, Jonathan
Horby, Peter
author_facet Salam, Alex Paddy
Cheng, Vincent
Edwards, Tansy
Olliaro, Piero
Sterne, Jonathan
Horby, Peter
author_sort Salam, Alex Paddy
collection PubMed
description Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some Lassa fever patients. An urgent reevaluation of ribavirin is therefore needed.
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spelling pubmed-82661112021-07-19 Time to reconsider the role of ribavirin in Lassa fever Salam, Alex Paddy Cheng, Vincent Edwards, Tansy Olliaro, Piero Sterne, Jonathan Horby, Peter PLoS Negl Trop Dis Viewpoints Ribavirin is the only available Lassa fever treatment. The rationale for using ribavirin is based on one clinical study conducted in the early 1980s. However, reanalysis of previous unpublished data reveals that ribavirin may actually be harmful in some Lassa fever patients. An urgent reevaluation of ribavirin is therefore needed. Public Library of Science 2021-07-08 /pmc/articles/PMC8266111/ /pubmed/34237063 http://dx.doi.org/10.1371/journal.pntd.0009522 Text en © 2021 Salam et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Viewpoints
Salam, Alex Paddy
Cheng, Vincent
Edwards, Tansy
Olliaro, Piero
Sterne, Jonathan
Horby, Peter
Time to reconsider the role of ribavirin in Lassa fever
title Time to reconsider the role of ribavirin in Lassa fever
title_full Time to reconsider the role of ribavirin in Lassa fever
title_fullStr Time to reconsider the role of ribavirin in Lassa fever
title_full_unstemmed Time to reconsider the role of ribavirin in Lassa fever
title_short Time to reconsider the role of ribavirin in Lassa fever
title_sort time to reconsider the role of ribavirin in lassa fever
topic Viewpoints
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266111/
https://www.ncbi.nlm.nih.gov/pubmed/34237063
http://dx.doi.org/10.1371/journal.pntd.0009522
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