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A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma
An accumulation of studies has indicated aging to be a significant hazard factor for the development of tumors. Cellular senescence is positively associated with aging progress and aging-related genes (AGs) can regulate cellular senescence and tumor malignancy. While the association between AGs and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266313/ https://www.ncbi.nlm.nih.gov/pubmed/34114970 http://dx.doi.org/10.18632/aging.203146 |
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author | Luo, Haitao Tao, Chuming Long, Xiaoyan Huang, Kai Zhu, Xingen |
author_facet | Luo, Haitao Tao, Chuming Long, Xiaoyan Huang, Kai Zhu, Xingen |
author_sort | Luo, Haitao |
collection | PubMed |
description | An accumulation of studies has indicated aging to be a significant hazard factor for the development of tumors. Cellular senescence is positively associated with aging progress and aging-related genes (AGs) can regulate cellular senescence and tumor malignancy. While the association between AGs and the prognosis of patients with glioma is still unclear. In our study, we initially selected four survival-associated AGs and performed consensus clustering for these AGs based on The Cancer Genome Atlas (TCGA) database. We then explored the potential biological effects of four selected AGs. A prognostic risk model was constructed according to four selected AGs (LEP, TERT, PON1, and SSTR3) in the TCGA dataset and Chinese Glioma Genome Atlas (CGGA) database. Then we indicated the risk score was an independent prognostic index, and was also positively correlated with immune scores, estimate score, immune cell infiltration level, programmed death ligand 1 (PD-L1) expression, and expression of proinflammatory factors in patients with glioma. Finally, we performed the RT-qPCR and immunohistochemistry assay to validate our bioinformatics results. Thus, this study indicated the risk model was concluded to possibly have potential function as an immune checkpoint inhibitor and to provide promising targets for developing individualized immunotherapies for patients with glioma. |
format | Online Article Text |
id | pubmed-8266313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-82663132021-07-09 A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma Luo, Haitao Tao, Chuming Long, Xiaoyan Huang, Kai Zhu, Xingen Aging (Albany NY) Research Paper An accumulation of studies has indicated aging to be a significant hazard factor for the development of tumors. Cellular senescence is positively associated with aging progress and aging-related genes (AGs) can regulate cellular senescence and tumor malignancy. While the association between AGs and the prognosis of patients with glioma is still unclear. In our study, we initially selected four survival-associated AGs and performed consensus clustering for these AGs based on The Cancer Genome Atlas (TCGA) database. We then explored the potential biological effects of four selected AGs. A prognostic risk model was constructed according to four selected AGs (LEP, TERT, PON1, and SSTR3) in the TCGA dataset and Chinese Glioma Genome Atlas (CGGA) database. Then we indicated the risk score was an independent prognostic index, and was also positively correlated with immune scores, estimate score, immune cell infiltration level, programmed death ligand 1 (PD-L1) expression, and expression of proinflammatory factors in patients with glioma. Finally, we performed the RT-qPCR and immunohistochemistry assay to validate our bioinformatics results. Thus, this study indicated the risk model was concluded to possibly have potential function as an immune checkpoint inhibitor and to provide promising targets for developing individualized immunotherapies for patients with glioma. Impact Journals 2021-06-10 /pmc/articles/PMC8266313/ /pubmed/34114970 http://dx.doi.org/10.18632/aging.203146 Text en Copyright: © 2021 Luo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Luo, Haitao Tao, Chuming Long, Xiaoyan Huang, Kai Zhu, Xingen A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title | A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title_full | A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title_fullStr | A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title_full_unstemmed | A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title_short | A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
title_sort | risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266313/ https://www.ncbi.nlm.nih.gov/pubmed/34114970 http://dx.doi.org/10.18632/aging.203146 |
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