Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CD...

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Autores principales: Grard, Marion, Chatelain, Camille, Delaunay, Tiphaine, Pons-Tostivint, Elvire, Bennouna, Jaafar, Fonteneau, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266377/
https://www.ncbi.nlm.nih.gov/pubmed/34249754
http://dx.doi.org/10.3389/fonc.2021.695770
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author Grard, Marion
Chatelain, Camille
Delaunay, Tiphaine
Pons-Tostivint, Elvire
Bennouna, Jaafar
Fonteneau, Jean-François
author_facet Grard, Marion
Chatelain, Camille
Delaunay, Tiphaine
Pons-Tostivint, Elvire
Bennouna, Jaafar
Fonteneau, Jean-François
author_sort Grard, Marion
collection PubMed
description Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.
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spelling pubmed-82663772021-07-09 Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy Grard, Marion Chatelain, Camille Delaunay, Tiphaine Pons-Tostivint, Elvire Bennouna, Jaafar Fonteneau, Jean-François Front Oncol Oncology Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-α, IFN-β…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring. Frontiers Media S.A. 2021-06-24 /pmc/articles/PMC8266377/ /pubmed/34249754 http://dx.doi.org/10.3389/fonc.2021.695770 Text en Copyright © 2021 Grard, Chatelain, Delaunay, Pons-Tostivint, Bennouna and Fonteneau https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Grard, Marion
Chatelain, Camille
Delaunay, Tiphaine
Pons-Tostivint, Elvire
Bennouna, Jaafar
Fonteneau, Jean-François
Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title_full Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title_fullStr Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title_full_unstemmed Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title_short Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy
title_sort homozygous co-deletion of type i interferons and cdkn2a genes in thoracic cancers: potential consequences for therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266377/
https://www.ncbi.nlm.nih.gov/pubmed/34249754
http://dx.doi.org/10.3389/fonc.2021.695770
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