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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase function. The principles for RET ligand-co-receptor recognition are incomple...

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Detalles Bibliográficos
Autores principales:	Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266384/ https://www.ncbi.nlm.nih.gov/pubmed/33484636 http://dx.doi.org/10.1016/j.str.2020.12.012

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