A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration

Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a neuronally expressed NAD(+) glycohydrolase whose activity is increased in response to stress. NAD(+) depletion triggers axonal degeneration, which is a characteristic feature of neurological diseases. Notably,...

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Detalles Bibliográficos
Autores principales: Loring, Heather S, Czech, Victoria L, Icso, Janneke D, O'Connor, Lauren, Parelkar, Sangram S, Byrne, Alexandra B, Thompson, Paul R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266388/
https://www.ncbi.nlm.nih.gov/pubmed/34184985
http://dx.doi.org/10.7554/eLife.66694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266388/
https://www.ncbi.nlm.nih.gov/pubmed/34184985
http://dx.doi.org/10.7554/eLife.66694

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