SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis

Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis and reduced bone formation was the main pathological change in GIOP. Our previous studies have shown that there was an imbalance between adipogenic and osteogenic differentiation in GIOP BM-MSCs and peroxisome proli...

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Detalles Bibliográficos
Autores principales: Zhang, Yongxing, Chen, Yang, Sun, Hangxiang, Zhang, Wenkan, Zhang, Lingling, Li, Hengyuan, Huang, Xin, Yang, Jie, Ye, Zhaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266396/
https://www.ncbi.nlm.nih.gov/pubmed/34249943
http://dx.doi.org/10.3389/fcell.2021.693079

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