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Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose

Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, the limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare worker...

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Autores principales: Rossi, Andres H., Ojeda, Diego S., Varese, Augusto, Sanchez, Lautaro, Gonzalez Lopez Ledesma, Maria M., Mazzitelli, Ignacio, Alvarez Juliá, Anabel, Oviedo Rouco, Santiago, Pallarés, Horacio M., Costa Navarro, Guadalupe S., Rasetto, Natali B., Garcia, Corina I., Wenker, Shirley D., Ramis, Lila Y., Bialer, Magalí G., de Leone, Maria Jose, Hernando, C. Esteban, Sosa, Santiago, Bianchimano, Luciana, Rios, Antonella S., Treffinger Cienfuegos, Maria Soledad, Caramelo, Julio J., Longueira, Yesica, Laufer, Natalia, Alvarez, Diego E., Carradori, Jorge, Pedrozza, Dariana, Rima, Alejandra, Echegoyen, Cecilia, Ercole, Regina, Gelpi, Paula, Marchetti, Susana, Zubieta, Martín, Docena, Guillermo, Kreplak, Nicolas, Yanovsky, Marcelo, Geffner, Jorge, Pifano, Marina, Gamarnik, Andrea V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266543/
https://www.ncbi.nlm.nih.gov/pubmed/34308389
http://dx.doi.org/10.1016/j.xcrm.2021.100359
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author Rossi, Andres H.
Ojeda, Diego S.
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
Garcia, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
de Leone, Maria Jose
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo
Kreplak, Nicolas
Yanovsky, Marcelo
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
author_facet Rossi, Andres H.
Ojeda, Diego S.
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
Garcia, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
de Leone, Maria Jose
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo
Kreplak, Nicolas
Yanovsky, Marcelo
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
author_sort Rossi, Andres H.
collection PubMed
description Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, the limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity after one and two doses in a cohort of naive or previously infected volunteers. By 21 days after receiving the first dose of the vaccine, 94% of naive participants develop spike-specific IgG antibodies. A single Sputnik V dose elicits higher antibody levels and virus-neutralizing capacity in previously infected individuals than in naive ones receiving the full two-dose schedule. The high seroconversion rate after a single dose in naive participants suggests a benefit of delaying administration of the second dose to increase the number of people vaccinated. The data presented provide information for guiding public health decisions in light of the current global health emergency.
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spelling pubmed-82665432021-07-20 Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose Rossi, Andres H. Ojeda, Diego S. Varese, Augusto Sanchez, Lautaro Gonzalez Lopez Ledesma, Maria M. Mazzitelli, Ignacio Alvarez Juliá, Anabel Oviedo Rouco, Santiago Pallarés, Horacio M. Costa Navarro, Guadalupe S. Rasetto, Natali B. Garcia, Corina I. Wenker, Shirley D. Ramis, Lila Y. Bialer, Magalí G. de Leone, Maria Jose Hernando, C. Esteban Sosa, Santiago Bianchimano, Luciana Rios, Antonella S. Treffinger Cienfuegos, Maria Soledad Caramelo, Julio J. Longueira, Yesica Laufer, Natalia Alvarez, Diego E. Carradori, Jorge Pedrozza, Dariana Rima, Alejandra Echegoyen, Cecilia Ercole, Regina Gelpi, Paula Marchetti, Susana Zubieta, Martín Docena, Guillermo Kreplak, Nicolas Yanovsky, Marcelo Geffner, Jorge Pifano, Marina Gamarnik, Andrea V. Cell Rep Med Report Massive vaccination offers great promise for halting the global COVID-19 pandemic. However, the limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluate SARS-CoV-2-specific antibody responses after Sputnik V vaccination of healthcare workers in Argentina, measuring IgG anti-spike titers and neutralizing capacity after one and two doses in a cohort of naive or previously infected volunteers. By 21 days after receiving the first dose of the vaccine, 94% of naive participants develop spike-specific IgG antibodies. A single Sputnik V dose elicits higher antibody levels and virus-neutralizing capacity in previously infected individuals than in naive ones receiving the full two-dose schedule. The high seroconversion rate after a single dose in naive participants suggests a benefit of delaying administration of the second dose to increase the number of people vaccinated. The data presented provide information for guiding public health decisions in light of the current global health emergency. Elsevier 2021-07-09 /pmc/articles/PMC8266543/ /pubmed/34308389 http://dx.doi.org/10.1016/j.xcrm.2021.100359 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Rossi, Andres H.
Ojeda, Diego S.
Varese, Augusto
Sanchez, Lautaro
Gonzalez Lopez Ledesma, Maria M.
Mazzitelli, Ignacio
Alvarez Juliá, Anabel
Oviedo Rouco, Santiago
Pallarés, Horacio M.
Costa Navarro, Guadalupe S.
Rasetto, Natali B.
Garcia, Corina I.
Wenker, Shirley D.
Ramis, Lila Y.
Bialer, Magalí G.
de Leone, Maria Jose
Hernando, C. Esteban
Sosa, Santiago
Bianchimano, Luciana
Rios, Antonella S.
Treffinger Cienfuegos, Maria Soledad
Caramelo, Julio J.
Longueira, Yesica
Laufer, Natalia
Alvarez, Diego E.
Carradori, Jorge
Pedrozza, Dariana
Rima, Alejandra
Echegoyen, Cecilia
Ercole, Regina
Gelpi, Paula
Marchetti, Susana
Zubieta, Martín
Docena, Guillermo
Kreplak, Nicolas
Yanovsky, Marcelo
Geffner, Jorge
Pifano, Marina
Gamarnik, Andrea V.
Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title_full Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title_fullStr Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title_full_unstemmed Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title_short Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose
title_sort sputnik v vaccine elicits seroconversion and neutralizing capacity to sars-cov-2 after a single dose
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266543/
https://www.ncbi.nlm.nih.gov/pubmed/34308389
http://dx.doi.org/10.1016/j.xcrm.2021.100359
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