Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging

R-loops are three-stranded nucleic acid structures with both physiological and pathological roles in cells. R-loop imaging generally relies on detection of the RNA–DNA hybrid component of these structures using the S9.6 antibody. We show that the use of this antibody for imaging can be problematic b...

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Detalles Bibliográficos
Autores principales: Crossley, Magdalena P., Brickner, Joshua R., Song, Chenlin, Zar, Su Mon Thin, Maw, Su S., Chédin, Frédéric, Tsai, Miaw-Sheue, Cimprich, Karlene A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266564/
https://www.ncbi.nlm.nih.gov/pubmed/34232287
http://dx.doi.org/10.1083/jcb.202101092

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