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Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA

The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of the toxin RnlA requires tight regulation by the an...

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Detalles Bibliográficos
Autores principales:	Garcia-Rodriguez, Gabriela, Charlier, Daniel, Wilmaerts, Dorien, Michiels, Jan, Loris, Remy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266594/ https://www.ncbi.nlm.nih.gov/pubmed/34139012 http://dx.doi.org/10.1093/nar/gkab513

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