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Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
The (m7)G cap is ubiquitous on RNAPII-transcribed RNA and has fundamental roles in eukaryotic gene expression, however its in vivo role in mammals has remained unknown. Here, we identified the (m7)G cap methyltransferase, RNMT, as a key mediator of T cell activation, which specifically regulates rib...
Autores principales: | Galloway, Alison, Kaskar, Aneesa, Ditsova, Dimitrinka, Atrih, Abdelmadjid, Yoshikawa, Harunori, Gomez-Moreira, Carolina, Suska, Olga, Warminski, Marcin, Grzela, Renata, Lamond, Angus I, Darzynkiewicz, Edward, Jemielity, Jacek, Cowling, Victoria H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266598/ https://www.ncbi.nlm.nih.gov/pubmed/34125914 http://dx.doi.org/10.1093/nar/gkab465 |
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