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Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

BACKGROUND: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive...

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Autores principales: Ong, Hui Lin, Isvoranu, Adela-Maria, Schirmbeck, Frederike, McGuire, Philip, Valmaggia, Lucia, Kempton, Matthew J, van der Gaag, Mark, Riecher-Rössler, Anita, Bressan, Rodrigo A, Barrantes-Vidal, Neus, Nelson, Barnaby, Amminger, G Paul, McGorry, Patrick, Pantelis, Christos, Krebs, Marie-Odile, Nordentoft, Merete, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P F, van Os, Jim, de Haan, Lieuwe, Borsboom, Denny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266672/
https://www.ncbi.nlm.nih.gov/pubmed/33595089
http://dx.doi.org/10.1093/schbul/sbaa187
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author Ong, Hui Lin
Isvoranu, Adela-Maria
Schirmbeck, Frederike
McGuire, Philip
Valmaggia, Lucia
Kempton, Matthew J
van der Gaag, Mark
Riecher-Rössler, Anita
Bressan, Rodrigo A
Barrantes-Vidal, Neus
Nelson, Barnaby
Amminger, G Paul
McGorry, Patrick
Pantelis, Christos
Krebs, Marie-Odile
Nordentoft, Merete
Glenthøj, Birte
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P F
van Os, Jim
de Haan, Lieuwe
Borsboom, Denny
author_facet Ong, Hui Lin
Isvoranu, Adela-Maria
Schirmbeck, Frederike
McGuire, Philip
Valmaggia, Lucia
Kempton, Matthew J
van der Gaag, Mark
Riecher-Rössler, Anita
Bressan, Rodrigo A
Barrantes-Vidal, Neus
Nelson, Barnaby
Amminger, G Paul
McGorry, Patrick
Pantelis, Christos
Krebs, Marie-Odile
Nordentoft, Merete
Glenthøj, Birte
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P F
van Os, Jim
de Haan, Lieuwe
Borsboom, Denny
author_sort Ong, Hui Lin
collection PubMed
description BACKGROUND: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. METHOD: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. RESULTS: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. CONCLUSIONS: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.
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spelling pubmed-82666722021-07-09 Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective Ong, Hui Lin Isvoranu, Adela-Maria Schirmbeck, Frederike McGuire, Philip Valmaggia, Lucia Kempton, Matthew J van der Gaag, Mark Riecher-Rössler, Anita Bressan, Rodrigo A Barrantes-Vidal, Neus Nelson, Barnaby Amminger, G Paul McGorry, Patrick Pantelis, Christos Krebs, Marie-Odile Nordentoft, Merete Glenthøj, Birte Ruhrmann, Stephan Sachs, Gabriele Rutten, Bart P F van Os, Jim de Haan, Lieuwe Borsboom, Denny Schizophr Bull Regular Articles BACKGROUND: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. METHOD: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GEI study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. RESULTS: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. CONCLUSIONS: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence. Oxford University Press 2021-02-17 /pmc/articles/PMC8266672/ /pubmed/33595089 http://dx.doi.org/10.1093/schbul/sbaa187 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Articles
Ong, Hui Lin
Isvoranu, Adela-Maria
Schirmbeck, Frederike
McGuire, Philip
Valmaggia, Lucia
Kempton, Matthew J
van der Gaag, Mark
Riecher-Rössler, Anita
Bressan, Rodrigo A
Barrantes-Vidal, Neus
Nelson, Barnaby
Amminger, G Paul
McGorry, Patrick
Pantelis, Christos
Krebs, Marie-Odile
Nordentoft, Merete
Glenthøj, Birte
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P F
van Os, Jim
de Haan, Lieuwe
Borsboom, Denny
Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title_full Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title_fullStr Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title_full_unstemmed Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title_short Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective
title_sort obsessive-compulsive symptoms and other symptoms of the at-risk mental state for psychosis: a network perspective
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266672/
https://www.ncbi.nlm.nih.gov/pubmed/33595089
http://dx.doi.org/10.1093/schbul/sbaa187
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