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Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting predominant involvement of mitochondria in generation of this defective SOS1-de...

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Detalles Bibliográficos
Autores principales:	García-Navas, Rósula, Liceras-Boillos, Pilar, Gómez, Carmela, Baltanás, Fernando C., Calzada, Nuria, Nuevo-Tapioles, Cristina, Cuezva, José M., Santos, Eugenio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266680/ https://www.ncbi.nlm.nih.gov/pubmed/34120142 http://dx.doi.org/10.1038/s41388-021-01886-3

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