Cargando…

Risk and Benefit for Targeted Therapy Agents in Pediatric Phase II Trials in Oncology: A Systematic Review with a Meta-Analysis

BACKGROUND: For research with human participants to be ethical, risk must be in a favorable balance with potential benefits. Little is known about the risk/benefit ratio for pediatric cancer phase II trials testing targeted therapies. OBJECTIVE: Our aim was to conduct a systematic review of prelimin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strzebonska, Karolina, Wasylewski, Mateusz T., Zaborowska, Lucja, Polak, Maciej, Slugocka, Emilia, Stras, Jakub, Blukacz, Mateusz, Gyawali, Bishal, Waligora, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Systematic Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266705/ https://www.ncbi.nlm.nih.gov/pubmed/34110559 http://dx.doi.org/10.1007/s11523-021-00822-5

Ejemplares similares

Risk and benefit for umbrella trials in oncology: a systematic review and meta-analysis
por: Strzebonska, Karolina, et al.
Publicado: (2022)

Clinical development success rates and social value of pediatric Phase 1 trials in oncology
por: Wasylewski, Mateusz T., et al.
Publicado: (2020)

Results dissemination of registered clinical trials across Polish academic institutions: a cross-sectional analysis
por: Strzebonska, Karolina, et al.
Publicado: (2020)

Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis
por: Waligora, Marcin, et al.
Publicado: (2018)

Umbrella and basket trials in oncology: ethical challenges
por: Strzebonska, Karolina, et al.
Publicado: (2019)

Ethical challenges of clinical trials with a repurposed drug in outbreaks
por: Klas, Katarzyna, et al.
Publicado: (2023)

Low-value practices in oncology contributing to financial toxicity
por: Gyawali, Bishal
Publicado: (2017)

What Global Oncology Needs: Mutual Learning and More Funding
por: Gyawali, Bishal, et al.
Publicado: (2018)

Text Messaging in Cancer-Supportive Care: A Systematic Review
por: Wijeratne, Don Thiwanka, et al.
Publicado: (2021)

Learning pain from others: a systematic review and meta-analysis of studies on placebo hypoalgesia and nocebo hyperalgesia induced by observational learning
por: Meeuwis, Stefanie H., et al.
Publicado: (2023)

Assessment of Price and Clinical Benefit of Cancer Drugs in Canada, 2011-2020
por: Jenei, Kristina, et al.
Publicado: (2023)

Assessing the benefits and harms of direct oral anticoagulants in patients with cancer for the prophylaxis and treatment of venous thromboembolism: a systematic review and meta-analysis
por: Desai, Aakash, et al.
Publicado: (2020)

How relevant for you is to be a moral person? Polish validation of the Self-Importance of Moral Identity Scale
por: Paruzel-Czachura, Mariola, et al.
Publicado: (2021)

Does the oncology community have a rejection bias when it comes to repurposed drugs?
por: Gyawali, Bishal, et al.
Publicado: (2018)

Quality of Life and Audiological Benefits in Pediatric Cochlear Implant Users in Romania: Systematic Review and Cohort Study
por: Gundacker, Gina, et al.
Publicado: (2023)

Assessing the risk-benefit profile of ramucirumab in patients with advanced solid tumors: A meta-analysis of randomized controlled trials
por: Effing, Sophie Marie Anne, et al.
Publicado: (2020)

Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases
por: Kaźmierczak-Siedlecka, Karolina, et al.
Publicado: (2020)

Association of Industry and Academic Sponsorship With Negative Phase 3 Oncology Trials and Reported Outcomes on Participant Survival: A Pooled Analysis
por: Addeo, Alfredo, et al.
Publicado: (2019)

The Relationship Between Spirituality, Health-Related Behavior, and Psychological Well-Being
por: Bożek, Agnieszka, et al.
Publicado: (2020)

Physical Activity, Sedentary Behavior, and Quality of Life among University Students
por: Nowak, Paweł F., et al.
Publicado: (2019)

Prognosis Communication in Pediatric Oncology: A Systematic Review
por: Boeriu, Estera, et al.
Publicado: (2023)

Oncologic Benefits of Neoadjuvant Treatment versus Upfront Surgery in Borderline Resectable Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: Jung, Hye-Sol, et al.
Publicado: (2022)

The Level of COVID-19 Anxiety among Oncology Patients in Poland
por: Grajek, Mateusz, et al.
Publicado: (2022)

Benefits of Treadmill Training for Patients with Down Syndrome: A Systematic Review
por: Kamińska, Karolina, et al.
Publicado: (2023)

Competition for recruitment in SARS-CoV-2 Trials in the United States: a longitudinal cohort analysis
por: Hutchinson, Nora, et al.
Publicado: (2022)

Antimicrobial Stewardship Interventions in Pediatric Oncology: A Systematic Review
por: Muratore, Edoardo, et al.
Publicado: (2022)

Physical and functional performance assessment in pediatric oncology: a systematic review
por: Söntgerath, Regine, et al.
Publicado: (2021)

The Influence of Serum Uric Acid Level on Non-Motor Symptoms Occurrence and Severity in Patients with Idiopathic Parkinson’s Disease and Atypical Parkinsonisms—A Systematic Review
por: Grażyńska, Anna, et al.
Publicado: (2021)

Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancer
por: Maciejewska, Natalia, et al.
Publicado: (2022)

Diagnosis and Management of Febrile Neutropenia in Pediatric Oncology Patients—A Systematic Review
por: Boeriu, Estera, et al.
Publicado: (2022)

Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent
por: Jendryczko, Karolina, et al.
Publicado: (2021)

Cancer drugs in LMICs: cheap but unaffordable
por: Gyawali, Bishal
Publicado: (2017)

The OlympiAD trial: who won the gold?
por: Gyawali, Bishal
Publicado: (2017)

Me, Too
por: Gyawali, Bishal
Publicado: (2016)

Letter to Editor-response: placebo response rates
por: Gyawali, Bishal
Publicado: (2023)

Oncology training programmes for general practitioners: a scoping review
por: Gyawali, Bishal, et al.
Publicado: (2021)

Training General Practitioners in Oncology: A Needs Assessment Survey From Nepal
por: Gyawali, Bishal, et al.
Publicado: (2022)

Training General Practitioners in Oncology: Lessons Learned From a Cross-Sectional Survey of GPOs in Canada
por: Gyawali, Bishal, et al.
Publicado: (2023)

Effect of Physical Activity on Static and Dynamic Postural Balance in Women Treated for Breast Cancer: A Systematic Review
por: Bula, Aleksandra, et al.
Publicado: (2023)

The Impact of Artificial Intelligence on Health Equity in Oncology: Scoping Review
por: Istasy, Paul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u87npln0uptclr5mc07sk61ft3