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The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury

PURPOSE: Sonlicromanol is a phase IIB clinical stage compound developed for treatment of mitochondrial diseases. Its active component, KH176m, functions as an antioxidant, directly scavenging reactive oxygen species (ROS), and redox activator, boosting the peroxiredoxin-thioredoxin system. Here, we...

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Detalles Bibliográficos
Autores principales:	Xiao, Yang, Yim, Karen, Zhang, Hong, Bakker, Diane, Nederlof, Rianne, Smeitink, Jan A. M., Renkema, Herma, Hollmann, Markus W., Weber, Nina C., Zuurbier, Coert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266721/ https://www.ncbi.nlm.nih.gov/pubmed/33914182 http://dx.doi.org/10.1007/s10557-021-07189-9

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