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Differential effects of body mass index on domain-specific cognitive outcomes after stroke

Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focu...

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Autores principales: Lee, Minwoo, Oh, Mi Sun, Jung, San, Lee, Ju-Hun, Kim, Chul-Ho, Jang, Min Uk, Kim, Young Eun, Bae, Hee-Joon, Park, Jaeseol, Kang, Yeonwook, Lee, Byung-Chul, Lim, Jae-Sung, Yu, Kyung-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266804/
https://www.ncbi.nlm.nih.gov/pubmed/34239011
http://dx.doi.org/10.1038/s41598-021-93714-7
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author Lee, Minwoo
Oh, Mi Sun
Jung, San
Lee, Ju-Hun
Kim, Chul-Ho
Jang, Min Uk
Kim, Young Eun
Bae, Hee-Joon
Park, Jaeseol
Kang, Yeonwook
Lee, Byung-Chul
Lim, Jae-Sung
Yu, Kyung-Ho
author_facet Lee, Minwoo
Oh, Mi Sun
Jung, San
Lee, Ju-Hun
Kim, Chul-Ho
Jang, Min Uk
Kim, Young Eun
Bae, Hee-Joon
Park, Jaeseol
Kang, Yeonwook
Lee, Byung-Chul
Lim, Jae-Sung
Yu, Kyung-Ho
author_sort Lee, Minwoo
collection PubMed
description Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focusing on the subdivision of each frontal domain function in post-ischemic stroke survivors. A total of 335 ischemic stroke patients were included in the study after completion of the Korean-Mini Mental Status Examination (K-MMSE) and the vascular cognitive impairment harmonization standards neuropsychological protocol at 3 months after stroke. Frontal lobe functions were analyzed using semantic/phonemic fluency, processing speed, and mental set shifting. Our study participants were categorized into four groups according to BMI quartiles. The z-scores of K-MMSE at 3 months differed significantly between the groups after adjustment for initial stroke severity (p = 0.014). Global cognitive function in stroke survivors in the Q1 (the lowest quartile) BMI group was significantly lower than those in Q2 and Q4 (the highest quartile) BMI groups (K-MMSE z-scores, Q1: − 2.10 ± 3.40 vs. Q2: 0.71 ± 1.95 and Q4: − 1.21 ± 1.65). Controlled oral word association test findings indicated that phonemic and semantic word fluency was lower in Q4 BMI group participants than in Q2 BMI group participants (p = 0.016 and p = 0.023 respectively). BMI might differentially affect cognitive domains after ischemic stroke. Although being underweight may negatively affect global cognition post-stroke, obesity could induce frontal lobe dysfunctions, specifically phonemic and semantic word fluency.
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spelling pubmed-82668042021-07-09 Differential effects of body mass index on domain-specific cognitive outcomes after stroke Lee, Minwoo Oh, Mi Sun Jung, San Lee, Ju-Hun Kim, Chul-Ho Jang, Min Uk Kim, Young Eun Bae, Hee-Joon Park, Jaeseol Kang, Yeonwook Lee, Byung-Chul Lim, Jae-Sung Yu, Kyung-Ho Sci Rep Article Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focusing on the subdivision of each frontal domain function in post-ischemic stroke survivors. A total of 335 ischemic stroke patients were included in the study after completion of the Korean-Mini Mental Status Examination (K-MMSE) and the vascular cognitive impairment harmonization standards neuropsychological protocol at 3 months after stroke. Frontal lobe functions were analyzed using semantic/phonemic fluency, processing speed, and mental set shifting. Our study participants were categorized into four groups according to BMI quartiles. The z-scores of K-MMSE at 3 months differed significantly between the groups after adjustment for initial stroke severity (p = 0.014). Global cognitive function in stroke survivors in the Q1 (the lowest quartile) BMI group was significantly lower than those in Q2 and Q4 (the highest quartile) BMI groups (K-MMSE z-scores, Q1: − 2.10 ± 3.40 vs. Q2: 0.71 ± 1.95 and Q4: − 1.21 ± 1.65). Controlled oral word association test findings indicated that phonemic and semantic word fluency was lower in Q4 BMI group participants than in Q2 BMI group participants (p = 0.016 and p = 0.023 respectively). BMI might differentially affect cognitive domains after ischemic stroke. Although being underweight may negatively affect global cognition post-stroke, obesity could induce frontal lobe dysfunctions, specifically phonemic and semantic word fluency. Nature Publishing Group UK 2021-07-08 /pmc/articles/PMC8266804/ /pubmed/34239011 http://dx.doi.org/10.1038/s41598-021-93714-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lee, Minwoo
Oh, Mi Sun
Jung, San
Lee, Ju-Hun
Kim, Chul-Ho
Jang, Min Uk
Kim, Young Eun
Bae, Hee-Joon
Park, Jaeseol
Kang, Yeonwook
Lee, Byung-Chul
Lim, Jae-Sung
Yu, Kyung-Ho
Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_full Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_fullStr Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_full_unstemmed Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_short Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_sort differential effects of body mass index on domain-specific cognitive outcomes after stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266804/
https://www.ncbi.nlm.nih.gov/pubmed/34239011
http://dx.doi.org/10.1038/s41598-021-93714-7
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