Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide

The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized that ATF4 is essential for the adaptation of...

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Detalles Bibliográficos
Autores principales: Lorenz, Nadja I., Sittig, Alina C. M., Urban, Hans, Luger, Anna-Luisa, Engel, Anna L., Münch, Christian, Steinbach, Joachim P., Ronellenfitsch, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266821/
https://www.ncbi.nlm.nih.gov/pubmed/34239013
http://dx.doi.org/10.1038/s41598-021-93663-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266821/
https://www.ncbi.nlm.nih.gov/pubmed/34239013
http://dx.doi.org/10.1038/s41598-021-93663-1

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