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Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). We hypothesized that ATF4 is essential for the adaptation of...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266821/ https://www.ncbi.nlm.nih.gov/pubmed/34239013 http://dx.doi.org/10.1038/s41598-021-93663-1 |