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An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function

The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo molecules. The expression of the VGF protein (nonacr...

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Detalles Bibliográficos
Autores principales: Lin, Wei-Jye, Zhao, Yan, Li, Zhe, Zheng, Shuyu, Zou, Jin-lin, Warren, Noël A., Bali, Purva, Wu, Jingru, Xing, Mengdan, Jiang, Cheng, Tang, Yamei, Salton, Stephen R., Ye, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266826/
https://www.ncbi.nlm.nih.gov/pubmed/34238925
http://dx.doi.org/10.1038/s41398-021-01489-2

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