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Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromoso...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266844/ https://www.ncbi.nlm.nih.gov/pubmed/34239025 http://dx.doi.org/10.1038/s41598-021-93691-x |
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author | Azulay, Rossana Santiago de Sousa Porto, Luís Cristóvão Silva, Dayse Aparecida Tavares, Maria da Glória Reis, Roberta Maria Duailibe Ferreira Nascimento, Gilvan Cortês Damianse, Sabrina da Silva Pereira Rocha, Viviane Chaves de Carvalho Magalhães, Marcelo Rodrigues, Vandilson Carvalho, Paulo Ricardo Vilas Boas Faria, Manuel dos Santos Gomes, Marília Brito |
author_facet | Azulay, Rossana Santiago de Sousa Porto, Luís Cristóvão Silva, Dayse Aparecida Tavares, Maria da Glória Reis, Roberta Maria Duailibe Ferreira Nascimento, Gilvan Cortês Damianse, Sabrina da Silva Pereira Rocha, Viviane Chaves de Carvalho Magalhães, Marcelo Rodrigues, Vandilson Carvalho, Paulo Ricardo Vilas Boas Faria, Manuel dos Santos Gomes, Marília Brito |
author_sort | Azulay, Rossana Santiago de Sousa |
collection | PubMed |
description | This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association. |
format | Online Article Text |
id | pubmed-8266844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82668442021-07-12 Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population Azulay, Rossana Santiago de Sousa Porto, Luís Cristóvão Silva, Dayse Aparecida Tavares, Maria da Glória Reis, Roberta Maria Duailibe Ferreira Nascimento, Gilvan Cortês Damianse, Sabrina da Silva Pereira Rocha, Viviane Chaves de Carvalho Magalhães, Marcelo Rodrigues, Vandilson Carvalho, Paulo Ricardo Vilas Boas Faria, Manuel dos Santos Gomes, Marília Brito Sci Rep Article This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association. Nature Publishing Group UK 2021-07-08 /pmc/articles/PMC8266844/ /pubmed/34239025 http://dx.doi.org/10.1038/s41598-021-93691-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Azulay, Rossana Santiago de Sousa Porto, Luís Cristóvão Silva, Dayse Aparecida Tavares, Maria da Glória Reis, Roberta Maria Duailibe Ferreira Nascimento, Gilvan Cortês Damianse, Sabrina da Silva Pereira Rocha, Viviane Chaves de Carvalho Magalhães, Marcelo Rodrigues, Vandilson Carvalho, Paulo Ricardo Vilas Boas Faria, Manuel dos Santos Gomes, Marília Brito Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title | Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title_full | Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title_fullStr | Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title_full_unstemmed | Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title_short | Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population |
title_sort | genetic ancestry inferred from autosomal and y chromosome markers and hla genotypes in type 1 diabetes from an admixed brazilian population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266844/ https://www.ncbi.nlm.nih.gov/pubmed/34239025 http://dx.doi.org/10.1038/s41598-021-93691-x |
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