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mTOR inhibitors potentially reduce TGF-β2-induced fibrogenic changes in trabecular meshwork cells

We examined the effects of mTOR inhibitors on the fibrotic response induced by transforming growth factor-beta2 (TGF-β2) in cultured human trabecular meshwork (hTM) cells. TGF-β2-induced expression of fibronectin, collagen type I, alpha 1 chain (COL1A1), and alpha-smooth muscle actin (αSMA) in hTM c...

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Detalles Bibliográficos
Autores principales:	Igarashi, Nozomi, Honjo, Megumi, Aihara, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266857/ https://www.ncbi.nlm.nih.gov/pubmed/34239027 http://dx.doi.org/10.1038/s41598-021-93580-3

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