βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are essential for RPE function and retinal health. Herein, we demonstrate an important role fo...

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Detalles Bibliográficos
Autores principales: Shang, Peng, Stepicheva, Nadezda, Teel, Kenneth, McCauley, Austin, Fitting, Christopher Scott, Hose, Stacey, Grebe, Rhonda, Yazdankhah, Meysam, Ghosh, Sayan, Liu, Haitao, Strizhakova, Anastasia, Weiss, Joseph, Bhutto, Imran A., Lutty, Gerard A., Jayagopal, Ashwath, Qian, Jiang, Sahel, José-Alain, Samuel Zigler, J., Handa, James T., Sergeev, Yuri, Rajala, Raju V. S., Watkins, Simon, Sinha, Debasish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266859/
https://www.ncbi.nlm.nih.gov/pubmed/34239035
http://dx.doi.org/10.1038/s42003-021-02386-6

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