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Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the impact of 5-hydroxyindoleacetic acid (5-HIAA)...

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Detalles Bibliográficos
Autores principales:	Tanaka, Takeshi, Mori, Masahiko, Sekino, Motohiro, Higashijima, Ushio, Takaki, Masahiro, Yamashita, Yoshiro, Kakiuchi, Satoshi, Tashiro, Masato, Morimoto, Konosuke, Tasaki, Osamu, Izumikawa, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266895/ https://www.ncbi.nlm.nih.gov/pubmed/34238999 http://dx.doi.org/10.1038/s41598-021-93649-z

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