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Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model

Synaptic loss in Alzheimer's disease (AD) is strongly correlated with cognitive impairment. Accumulating evidence indicates that amyloid pathology leads to synaptic degeneration and mitochondrial damage in AD. However, it remains unclear whether synapses and presynaptic mitochondria are differe...

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Detalles Bibliográficos
Autores principales:	Seo, Na-young, Kim, Gyu Hyun, Noh, Jeong Eun, Shin, Ji Won, Lee, Chan Hee, Lee, Kea Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267061/ https://www.ncbi.nlm.nih.gov/pubmed/34248509 http://dx.doi.org/10.3389/fnana.2021.690168

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