Ppp6c deficiency accelerates K‐ras (G12D) ‐induced tongue carcinogenesis

BACKGROUND: Effective treatments for cancer harboring mutant RAS are lacking. In Drosophila, it was reported that PP6 suppresses tumorigenicity of mutant RAS. However, the information how PP6 regulates oncogenic RAS in mammals is limited. METHODS: We examined the effects of PP6 gene (Ppp6c) deficien...

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Detalles Bibliográficos
Autores principales: Kishimoto, Kazuhiro, Kanazawa, Kosuke, Nomura, Miyuki, Tanaka, Takuji, Shigemoto‐Kuroda, Taeko, Fukui, Katsuya, Miura, Koh, Kurosawa, Koreyuki, Kawai, Masaaki, Kato, Hiroyuki, Terasaki, Keiko, Sakamoto, Yoshimi, Yamashita, Yoji, Sato, Ikuro, Tanuma, Nobuhiro, Tamai, Keiichi, Kitabayashi, Issay, Matsuura, Kazuto, Watanabe, Toshio, Yasuda, Jun, Tsuji, Hiroyuki, Shima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267137/
https://www.ncbi.nlm.nih.gov/pubmed/34145991
http://dx.doi.org/10.1002/cam4.3962

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