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Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke
Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional out...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267172/ https://www.ncbi.nlm.nih.gov/pubmed/34248685 http://dx.doi.org/10.3389/fpsyt.2021.556981 |
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author | Zeng, Ya-Ying Wu, Meng-Xuan Zhou, Sheng-Nan Geng, Dan-Dan Cheng, Lin Fan, Kai-Li Yu, Xin Tang, Wen-Jie He, Jin-Cai |
author_facet | Zeng, Ya-Ying Wu, Meng-Xuan Zhou, Sheng-Nan Geng, Dan-Dan Cheng, Lin Fan, Kai-Li Yu, Xin Tang, Wen-Jie He, Jin-Cai |
author_sort | Zeng, Ya-Ying |
collection | PubMed |
description | Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment. Methods: Four hundred thirty-six patients who met the criteria were included in this study from October 2013 to February 2015. The follow-up time for each patient was ~5 years, with follow-up every 3 months. Patients received questionnaires including the 17-item Hamilton Depression Scale (HAMD), the Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel Index (BI). Results: Of the 436 patients, 154 (35.3%) patients with the prevalence of PSD status at baseline, 26 (7.2%) patients with the prevalence of PSD status, and 73 (20.1%) had an unfavorable outcome 5 years after stroke. The odds ratio (OR) for unfavorable outcome at 5 years in the PSD group was ~2.2 relative to the non-PSD group after adjusting for potential risk factors [OR = 2.217, 95% confidence interval (CI) = 1.179–4.421, P = 0.015]. In the early-onset PSD group, HAMD scores were independently associated with 5-year unfavorable outcome rates (OR = 1.168, 95% CI = 1.015–1.345, P = 0.031). Conclusions: Our findings indicate that early-onset PSD status in Chinese patients is an independent risk factor for unfavorable outcome 5 years after stroke, and that the severity of PSD is also related to unfavorable outcome. |
format | Online Article Text |
id | pubmed-8267172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82671722021-07-10 Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke Zeng, Ya-Ying Wu, Meng-Xuan Zhou, Sheng-Nan Geng, Dan-Dan Cheng, Lin Fan, Kai-Li Yu, Xin Tang, Wen-Jie He, Jin-Cai Front Psychiatry Psychiatry Background: Post-stroke depression (PSD) constitutes an essential complication of stroke and is associated with high-risk unfavorable outcome after stroke. The main objective of this prospective study was to determine the relationship between early-onset PSD (1 month after stroke) and functional outcomes 5 years after baseline enrollment. Methods: Four hundred thirty-six patients who met the criteria were included in this study from October 2013 to February 2015. The follow-up time for each patient was ~5 years, with follow-up every 3 months. Patients received questionnaires including the 17-item Hamilton Depression Scale (HAMD), the Mini-Mental State Examination (MMSE), the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel Index (BI). Results: Of the 436 patients, 154 (35.3%) patients with the prevalence of PSD status at baseline, 26 (7.2%) patients with the prevalence of PSD status, and 73 (20.1%) had an unfavorable outcome 5 years after stroke. The odds ratio (OR) for unfavorable outcome at 5 years in the PSD group was ~2.2 relative to the non-PSD group after adjusting for potential risk factors [OR = 2.217, 95% confidence interval (CI) = 1.179–4.421, P = 0.015]. In the early-onset PSD group, HAMD scores were independently associated with 5-year unfavorable outcome rates (OR = 1.168, 95% CI = 1.015–1.345, P = 0.031). Conclusions: Our findings indicate that early-onset PSD status in Chinese patients is an independent risk factor for unfavorable outcome 5 years after stroke, and that the severity of PSD is also related to unfavorable outcome. Frontiers Media S.A. 2021-06-25 /pmc/articles/PMC8267172/ /pubmed/34248685 http://dx.doi.org/10.3389/fpsyt.2021.556981 Text en Copyright © 2021 Zeng, Wu, Zhou, Geng, Cheng, Fan, Yu, Tang and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zeng, Ya-Ying Wu, Meng-Xuan Zhou, Sheng-Nan Geng, Dan-Dan Cheng, Lin Fan, Kai-Li Yu, Xin Tang, Wen-Jie He, Jin-Cai Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title | Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title_full | Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title_fullStr | Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title_full_unstemmed | Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title_short | Early-Onset Depression in Stroke Patients: Effects on Unfavorable Outcome 5 Years Post-stroke |
title_sort | early-onset depression in stroke patients: effects on unfavorable outcome 5 years post-stroke |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267172/ https://www.ncbi.nlm.nih.gov/pubmed/34248685 http://dx.doi.org/10.3389/fpsyt.2021.556981 |
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