The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus

We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, r...

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Autores principales: SUDO, Kasumi, YAMADA, Manabu, OCHIAI, Mariko, IWAMOTO, Shoko, SAKAKI, Hajime, KUSHIDA, Chiho, YAMASHITA, Maiko, YAMAMOTO, Atsushi, NAGASAKA, Takao, OIDEMIZU, Mikio, SAITO, Akito, YAMAMOTO, Kinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267204/
https://www.ncbi.nlm.nih.gov/pubmed/33867396
http://dx.doi.org/10.1292/jvms.20-0654
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author SUDO, Kasumi
YAMADA, Manabu
OCHIAI, Mariko
IWAMOTO, Shoko
SAKAKI, Hajime
KUSHIDA, Chiho
YAMASHITA, Maiko
YAMAMOTO, Atsushi
NAGASAKA, Takao
OIDEMIZU, Mikio
SAITO, Akito
YAMAMOTO, Kinya
author_facet SUDO, Kasumi
YAMADA, Manabu
OCHIAI, Mariko
IWAMOTO, Shoko
SAKAKI, Hajime
KUSHIDA, Chiho
YAMASHITA, Maiko
YAMAMOTO, Atsushi
NAGASAKA, Takao
OIDEMIZU, Mikio
SAITO, Akito
YAMAMOTO, Kinya
author_sort SUDO, Kasumi
collection PubMed
description We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs.
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spelling pubmed-82672042021-07-14 The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus SUDO, Kasumi YAMADA, Manabu OCHIAI, Mariko IWAMOTO, Shoko SAKAKI, Hajime KUSHIDA, Chiho YAMASHITA, Maiko YAMAMOTO, Atsushi NAGASAKA, Takao OIDEMIZU, Mikio SAITO, Akito YAMAMOTO, Kinya J Vet Med Sci Pathology We evaluated the role of classical swine fever virus (CSFV) in the formation of button ulcers in the mucosa of the gastrointestinal tract. Histopathological and immunohistochemical analyses of pigs experimentally infected with a subgenotype 2.1 isolate of CSFV, which was isolated in Japan in 2019, revealed follicular necrosis in the submucosal mucosa-associated lymphoid tissue and herniation of crypts as factors that contribute to the development of button ulcers during CSFV infection. These findings indicate that CSFV induces follicular necrosis and is one of the causative agents of button ulcers in pigs. The Japanese Society of Veterinary Science 2021-04-19 2021-06 /pmc/articles/PMC8267204/ /pubmed/33867396 http://dx.doi.org/10.1292/jvms.20-0654 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
SUDO, Kasumi
YAMADA, Manabu
OCHIAI, Mariko
IWAMOTO, Shoko
SAKAKI, Hajime
KUSHIDA, Chiho
YAMASHITA, Maiko
YAMAMOTO, Atsushi
NAGASAKA, Takao
OIDEMIZU, Mikio
SAITO, Akito
YAMAMOTO, Kinya
The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title_full The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title_fullStr The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title_full_unstemmed The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title_short The formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
title_sort formation process of button ulcers in pigs experimentally infected with a subgenotype 2.1 isolate of classical swine fever virus
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267204/
https://www.ncbi.nlm.nih.gov/pubmed/33867396
http://dx.doi.org/10.1292/jvms.20-0654
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