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Surgical treatment of locally recurrent rectal cancer: a narrative review

OBJECTIVE: To summarize the recent literature on surgical treatment of locally recurrent rectal cancer (LRRC). BACKGROUND: LRRC is a heterogeneous disease that requires a multidisciplinary treatment approach. The treatment and prognosis depend on the site and type of recurrence. Radical resection re...

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Autores principales: Gao, Zhaoya, Gu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267292/
https://www.ncbi.nlm.nih.gov/pubmed/34277826
http://dx.doi.org/10.21037/atm-21-2298
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author Gao, Zhaoya
Gu, Jin
author_facet Gao, Zhaoya
Gu, Jin
author_sort Gao, Zhaoya
collection PubMed
description OBJECTIVE: To summarize the recent literature on surgical treatment of locally recurrent rectal cancer (LRRC). BACKGROUND: LRRC is a heterogeneous disease that requires a multidisciplinary treatment approach. The treatment and prognosis depend on the site and type of recurrence. Radical resection remains the primary method for achieving long-term survival and improving symptom control. Preoperative chemoradiotherapy can reduce tumor volume and improve the R0 resection rate. Surgeons must clearly understand pelvic anatomy, develop a detailed preoperative plan, adopt a multidisciplinary approach for the surgical resection of the tumor as well as any invaded soft tissues, vessels, and bones, and ensure proper reconstruction. However, extended radical surgery often leads to a higher risk of postoperative complications and a low quality of life. METHODS: We searched English-language articles with keywords “locally recurrent rectal cancer”, “surgery” and “multidisciplinary team” in PubMed published between January 2000 to October 2020. CONCLUSIONS: LRRC is a complex problem. Long-term survival is not impossible following multidisciplinary treatment in appropriately selected LRRC patients. The management of LRRC relies on a specialist team that determines the biological behavior of the tumor and evaluates treatment options through multidisciplinary discussions, thereby balancing the surgical costs and benefits, alleviating postoperative complications, and improving patients’ quality of life.
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spelling pubmed-82672922021-07-16 Surgical treatment of locally recurrent rectal cancer: a narrative review Gao, Zhaoya Gu, Jin Ann Transl Med Review Article OBJECTIVE: To summarize the recent literature on surgical treatment of locally recurrent rectal cancer (LRRC). BACKGROUND: LRRC is a heterogeneous disease that requires a multidisciplinary treatment approach. The treatment and prognosis depend on the site and type of recurrence. Radical resection remains the primary method for achieving long-term survival and improving symptom control. Preoperative chemoradiotherapy can reduce tumor volume and improve the R0 resection rate. Surgeons must clearly understand pelvic anatomy, develop a detailed preoperative plan, adopt a multidisciplinary approach for the surgical resection of the tumor as well as any invaded soft tissues, vessels, and bones, and ensure proper reconstruction. However, extended radical surgery often leads to a higher risk of postoperative complications and a low quality of life. METHODS: We searched English-language articles with keywords “locally recurrent rectal cancer”, “surgery” and “multidisciplinary team” in PubMed published between January 2000 to October 2020. CONCLUSIONS: LRRC is a complex problem. Long-term survival is not impossible following multidisciplinary treatment in appropriately selected LRRC patients. The management of LRRC relies on a specialist team that determines the biological behavior of the tumor and evaluates treatment options through multidisciplinary discussions, thereby balancing the surgical costs and benefits, alleviating postoperative complications, and improving patients’ quality of life. AME Publishing Company 2021-06 /pmc/articles/PMC8267292/ /pubmed/34277826 http://dx.doi.org/10.21037/atm-21-2298 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
Gao, Zhaoya
Gu, Jin
Surgical treatment of locally recurrent rectal cancer: a narrative review
title Surgical treatment of locally recurrent rectal cancer: a narrative review
title_full Surgical treatment of locally recurrent rectal cancer: a narrative review
title_fullStr Surgical treatment of locally recurrent rectal cancer: a narrative review
title_full_unstemmed Surgical treatment of locally recurrent rectal cancer: a narrative review
title_short Surgical treatment of locally recurrent rectal cancer: a narrative review
title_sort surgical treatment of locally recurrent rectal cancer: a narrative review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267292/
https://www.ncbi.nlm.nih.gov/pubmed/34277826
http://dx.doi.org/10.21037/atm-21-2298
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