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Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome

OBJECTIVE: To evaluate racial differences in the anxiety and depression prevalence and scores in women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional. SETTING: Academic institution. PATIENT(S): Reproductive-aged women with PCOS (n = 272) and controls (n = 295). INTERVENTION(S): Hospi...

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Autores principales: Alur-Gupta, Snigdha, Lee, Iris, Chemerinski, Anat, Liu, Chang, Lipson, Jenna, Allison, Kelly, Gallop, Robert, Dokras, Anuja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267396/
https://www.ncbi.nlm.nih.gov/pubmed/34278359
http://dx.doi.org/10.1016/j.xfre.2021.03.003
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author Alur-Gupta, Snigdha
Lee, Iris
Chemerinski, Anat
Liu, Chang
Lipson, Jenna
Allison, Kelly
Gallop, Robert
Dokras, Anuja
author_facet Alur-Gupta, Snigdha
Lee, Iris
Chemerinski, Anat
Liu, Chang
Lipson, Jenna
Allison, Kelly
Gallop, Robert
Dokras, Anuja
author_sort Alur-Gupta, Snigdha
collection PubMed
description OBJECTIVE: To evaluate racial differences in the anxiety and depression prevalence and scores in women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional. SETTING: Academic institution. PATIENT(S): Reproductive-aged women with PCOS (n = 272) and controls (n = 295). INTERVENTION(S): Hospital anxiety and depression scale and modified PCOS quality-of-life survey (MPCOS-Q). MAIN OUTCOME MEASURE(S): Differences in depression and anxiety scores and quality-of-life score measured using the hospital anxiety and depression scale and MPCOS-Q were determined between White and Black women with PCOS. Multivariable correlation regressions assessed the association of the Ferriman-Gallwey score, total testosterone, body mass index (BMI), and homeostatic model assessment of insulin resistance with anxiety, depression, and quality-of-life scores. RESULT(S): Multivariable regression controlling for age, BMI, and socioeconomic status showed that White women with PCOS had a significantly higher prevalence of anxiety than Black women with PCOS (75.9% vs. 61.3%) and significantly higher anxiety scores (mean ± SD, 10.3 ± 4.1 vs. 8.7 ± 4.6). The prevalence of depression (24.4% vs. 29%) and depression scores (4.8 ± 3.6 vs. 5.1 ± 4.0) was not significantly different. In multivariable correlation regressions, the interaction between BMI and race in its association with anxiety scores was significant. The association of race with Ferriman-Gallwey score, total testosterone, or homeostatic model assessment of insulin resistance was not significant. In multivariable models, although the total MPCOS-Q scores were similar, the infertility domain was significantly lower in Black women with PCOS (mean ± SD, 12.6 ± 7.8 vs. 17.5 ± 6.8) indicating a lower quality of life related to infertility. CONCLUSION: Racial differences identified in the prevalence of anxiety and MPCOS-Q domains suggest the importance of routine screening and provide an opportunity for targeted interventions based on race.
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spelling pubmed-82673962021-07-16 Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome Alur-Gupta, Snigdha Lee, Iris Chemerinski, Anat Liu, Chang Lipson, Jenna Allison, Kelly Gallop, Robert Dokras, Anuja F S Rep Original Article OBJECTIVE: To evaluate racial differences in the anxiety and depression prevalence and scores in women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional. SETTING: Academic institution. PATIENT(S): Reproductive-aged women with PCOS (n = 272) and controls (n = 295). INTERVENTION(S): Hospital anxiety and depression scale and modified PCOS quality-of-life survey (MPCOS-Q). MAIN OUTCOME MEASURE(S): Differences in depression and anxiety scores and quality-of-life score measured using the hospital anxiety and depression scale and MPCOS-Q were determined between White and Black women with PCOS. Multivariable correlation regressions assessed the association of the Ferriman-Gallwey score, total testosterone, body mass index (BMI), and homeostatic model assessment of insulin resistance with anxiety, depression, and quality-of-life scores. RESULT(S): Multivariable regression controlling for age, BMI, and socioeconomic status showed that White women with PCOS had a significantly higher prevalence of anxiety than Black women with PCOS (75.9% vs. 61.3%) and significantly higher anxiety scores (mean ± SD, 10.3 ± 4.1 vs. 8.7 ± 4.6). The prevalence of depression (24.4% vs. 29%) and depression scores (4.8 ± 3.6 vs. 5.1 ± 4.0) was not significantly different. In multivariable correlation regressions, the interaction between BMI and race in its association with anxiety scores was significant. The association of race with Ferriman-Gallwey score, total testosterone, or homeostatic model assessment of insulin resistance was not significant. In multivariable models, although the total MPCOS-Q scores were similar, the infertility domain was significantly lower in Black women with PCOS (mean ± SD, 12.6 ± 7.8 vs. 17.5 ± 6.8) indicating a lower quality of life related to infertility. CONCLUSION: Racial differences identified in the prevalence of anxiety and MPCOS-Q domains suggest the importance of routine screening and provide an opportunity for targeted interventions based on race. Elsevier 2021-03-13 /pmc/articles/PMC8267396/ /pubmed/34278359 http://dx.doi.org/10.1016/j.xfre.2021.03.003 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Alur-Gupta, Snigdha
Lee, Iris
Chemerinski, Anat
Liu, Chang
Lipson, Jenna
Allison, Kelly
Gallop, Robert
Dokras, Anuja
Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title_full Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title_fullStr Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title_full_unstemmed Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title_short Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
title_sort racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267396/
https://www.ncbi.nlm.nih.gov/pubmed/34278359
http://dx.doi.org/10.1016/j.xfre.2021.03.003
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