Contiguous erosion of the inactive X in human pluripotency concludes with global DNA hypomethylation

Female human pluripotent stem cells (hPSCs) routinely undergo inactive X (Xi) erosion. This progressive loss of key repressive features follows the loss of XIST expression, the long non-coding RNA driving X inactivation, and causes reactivation of silenced genes across the eroding X (Xe). To date, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bansal, Prakhar, Ahern, Darcy T., Kondaveeti, Yuvabharath, Qiu, Catherine W., Pinter, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267460/
https://www.ncbi.nlm.nih.gov/pubmed/34107261
http://dx.doi.org/10.1016/j.celrep.2021.109215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267460/
https://www.ncbi.nlm.nih.gov/pubmed/34107261
http://dx.doi.org/10.1016/j.celrep.2021.109215

Ejemplares similares