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Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory
In the fifteen minutes it takes to read this short commentary, more than 400 babies will have been born too early, another 300 expecting mothers will develop preeclampsia, and 75 unborn third trimester fetuses will have died in utero (stillbirth). Given the lack of meaningful progress in understandi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267465/ https://www.ncbi.nlm.nih.gov/pubmed/34248991 http://dx.doi.org/10.3389/fimmu.2021.693189 |
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author | Gregory, Emily J. Liu, James Miller-Handley, Hilary Kinder, Jeremy M. Way, Sing Sing |
author_facet | Gregory, Emily J. Liu, James Miller-Handley, Hilary Kinder, Jeremy M. Way, Sing Sing |
author_sort | Gregory, Emily J. |
collection | PubMed |
description | In the fifteen minutes it takes to read this short commentary, more than 400 babies will have been born too early, another 300 expecting mothers will develop preeclampsia, and 75 unborn third trimester fetuses will have died in utero (stillbirth). Given the lack of meaningful progress in understanding the physiological changes that occur to allow a healthy, full term pregnancy, it is perhaps not surprising that effective therapies against these great obstetrical syndromes that include prematurity, preeclampsia, and stillbirth remain elusive. Meanwhile, pregnancy complications remain the leading cause of infant and childhood mortality under age five. Does it have to be this way? What more can we collectively, as a biomedical community, or individually, as clinicians who care for women and newborn babies at high risk for pregnancy complications, do to protect individuals in these extremely vulnerable developmental windows? The problem of pregnancy complications and neonatal mortality is extraordinarily complex, with multiple unique, but complementary perspectives from scientific, epidemiological and public health viewpoints. Herein, we discuss the epidemiology of pregnancy complications, focusing on how the outcome of prior pregnancy impacts the risk of complication in the next pregnancy — and how the fundamental immunological principle of memory may promote this adaptive response. |
format | Online Article Text |
id | pubmed-8267465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82674652021-07-10 Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory Gregory, Emily J. Liu, James Miller-Handley, Hilary Kinder, Jeremy M. Way, Sing Sing Front Immunol Immunology In the fifteen minutes it takes to read this short commentary, more than 400 babies will have been born too early, another 300 expecting mothers will develop preeclampsia, and 75 unborn third trimester fetuses will have died in utero (stillbirth). Given the lack of meaningful progress in understanding the physiological changes that occur to allow a healthy, full term pregnancy, it is perhaps not surprising that effective therapies against these great obstetrical syndromes that include prematurity, preeclampsia, and stillbirth remain elusive. Meanwhile, pregnancy complications remain the leading cause of infant and childhood mortality under age five. Does it have to be this way? What more can we collectively, as a biomedical community, or individually, as clinicians who care for women and newborn babies at high risk for pregnancy complications, do to protect individuals in these extremely vulnerable developmental windows? The problem of pregnancy complications and neonatal mortality is extraordinarily complex, with multiple unique, but complementary perspectives from scientific, epidemiological and public health viewpoints. Herein, we discuss the epidemiology of pregnancy complications, focusing on how the outcome of prior pregnancy impacts the risk of complication in the next pregnancy — and how the fundamental immunological principle of memory may promote this adaptive response. Frontiers Media S.A. 2021-06-25 /pmc/articles/PMC8267465/ /pubmed/34248991 http://dx.doi.org/10.3389/fimmu.2021.693189 Text en Copyright © 2021 Gregory, Liu, Miller-Handley, Kinder and Way https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gregory, Emily J. Liu, James Miller-Handley, Hilary Kinder, Jeremy M. Way, Sing Sing Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title | Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title_full | Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title_fullStr | Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title_full_unstemmed | Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title_short | Epidemiology of Pregnancy Complications Through the Lens of Immunological Memory |
title_sort | epidemiology of pregnancy complications through the lens of immunological memory |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267465/ https://www.ncbi.nlm.nih.gov/pubmed/34248991 http://dx.doi.org/10.3389/fimmu.2021.693189 |
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