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Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles

GPR17 is a G-protein-coupled receptor (GPCR) implicated in the regulation of glucose metabolism and energy homeostasis. Such evidence is primarily drawn from mouse knockout studies and suggests GPR17 as a potential novel therapeutic target for the treatment of metabolic diseases. However, links betw...

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Detalles Bibliográficos
Autores principales:	Conley, Jason M., Sun, Hongmao, Ayers, Kristin L., Zhu, Hu, Chen, Rong, Shen, Min, Hall, Matthew D., Ren, Hongxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267566/ https://www.ncbi.nlm.nih.gov/pubmed/34144038 http://dx.doi.org/10.1016/j.jbc.2021.100881

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