Hydroxychloroquine (HCQ) Modulates Autophagy and Oxidative DNA Damage Stress in Hepatocellular Carcinoma to Overcome Sorafenib Resistance via TLR9/SOD1/hsa-miR-30a-5p/Beclin-1 Axis

SIMPLE SUMMARY: Hepatocellular carcinoma (HCC) is one of the major causes of cancer-associated death worldwide. Development of sorafenib resistance presents a major failure of HCC therapy. We applied a combination therapy approach of hydroxychloroquine (HCQ)–sorafenib, both in vitro and in vivo, wit...

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Detalles Bibliográficos
Autores principales: Chen, Ming-Yao, Yadav, Vijesh Kumar, Chu, Yi Cheng, Ong, Jiann Ruey, Huang, Ting-Yi, Lee, Kwai-Fong, Lee, Kuen-Haur, Yeh, Chi-Tai, Lee, Wei-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267639/
https://www.ncbi.nlm.nih.gov/pubmed/34203465
http://dx.doi.org/10.3390/cancers13133227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267639/
https://www.ncbi.nlm.nih.gov/pubmed/34203465
http://dx.doi.org/10.3390/cancers13133227

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