Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that miR-125b inhibited osteoclast formation by targeting Prdm1 encoding a transcriptional repressor of anti-osteoclastogenesis factors. Transgenic (...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267655/
https://www.ncbi.nlm.nih.gov/pubmed/34201781
http://dx.doi.org/10.3390/ijms22136745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267655/
https://www.ncbi.nlm.nih.gov/pubmed/34201781
http://dx.doi.org/10.3390/ijms22136745

Ejemplares similares