Cargando…

Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that miR-125b inhibited osteoclast formation by targeting Prdm1 encoding a transcriptional repressor of anti-osteoclastogenesis factors. Transgenic (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267655/ https://www.ncbi.nlm.nih.gov/pubmed/34201781 http://dx.doi.org/10.3390/ijms22136745

Ejemplares similares

Single‐Cell RNA‐Sequencing Reveals the Breadth of Osteoblast Heterogeneity
por: Yoshioka, Hirotaka, et al.
Publicado: (2021)

The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice
por: Minamizaki, Tomoko, et al.
Publicado: (2020)

A Subset of Osteoblasts Expressing High Endogenous Levels of PPARγ Switches Fate to Adipocytes in the Rat Calvaria Cell Culture Model
por: Yoshiko, Yuji, et al.
Publicado: (2010)

1α,25-dihydroxyvitamin D(3) acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro
por: Yamamoto, Ryoko, et al.
Publicado: (2010)

Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling
por: Kawamura, Naohiro, et al.
Publicado: (2007)

Overexpression of Neurogenin 1 Negatively Regulates Osteoclast and Osteoblast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2022)

Functional Diversity of Fibroblast Growth Factors in Bone Formation
por: Takei, Yuichiro, et al.
Publicado: (2015)

Developmental impairments of craniofacial bone and cartilage in transgenic mice expressing FGF10
por: Yoshioka, Hirotaka, et al.
Publicado: (2023)

Anti-c-fms Antibody Prevents Osteoclast Formation and Bone Resorption in Co-Culture of Osteoblasts and Osteoclast Precursors In Vitro and in Ovariectomized Mice
por: Nara, Yasuhiko, et al.
Publicado: (2020)

Imaging and mapping of mouse bone using MALDI-imaging mass spectrometry
por: Fujino, Yoko, et al.
Publicado: (2016)

Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture
por: Meng, Guolong, et al.
Publicado: (2019)

Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis
por: Moriishi, Takeshi, et al.
Publicado: (2011)

Osteoblast-Osteoclast Communication and Bone Homeostasis
por: Kim, Jung-Min, et al.
Publicado: (2020)

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
por: Furuya, Masayuki, et al.
Publicado: (2018)

Overexpression of PIK3R1 Promotes Bone Formation by Regulating Osteoblast Differentiation and Osteoclast Formation
por: Zhu, Haitao, et al.
Publicado: (2021)

Primary mouse osteoblast and osteoclast culturing and analysis
por: Chevalier, Claire, et al.
Publicado: (2021)

Retracted: Overexpression of PIK3R1 Promotes Bone Formation by Regulating Osteoblast Differentiation and Osteoclast Formation
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Signaling pathways regulating the specification and differentiation of the osteoblast lineage
por: Hojo, Hironori, et al.
Publicado: (2015)

An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts
por: Amano, Hitoshi, et al.
Publicado: (2019)

Osteoclastic bone resorption directly activates osteoblast function
por: Udagawa, Nobuyuki
Publicado: (2012)

Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts
por: Kupisiewicz, Katarzyna, et al.
Publicado: (2010)

Commensal Microbiota Enhance Both Osteoclast and Osteoblast Activities
por: Uchida, Yoko, et al.
Publicado: (2018)

Molecular Modulation of Osteoblasts and Osteoclasts in Type 2 Diabetes
por: Rathinavelu, Selvalakshmi, et al.
Publicado: (2018)

Myonectin inhibits the differentiation of osteoblasts and osteoclasts in mouse cells
por: Kawaguchi, Miku, et al.
Publicado: (2020)

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast–Osteoblasts Communication in Bone Remodeling
por: Yuan, Feng-Lai, et al.
Publicado: (2018)

Gli1 Haploinsufficiency Leads to Decreased Bone Mass with an Uncoupling of Bone Metabolism in Adult Mice
por: Kitaura, Yoshiaki, et al.
Publicado: (2014)

Dynamic imaging of the effect of mesenchymal stem cells on osteoclast precursor cell chemotaxis for bone defects in the mouse skull
por: Abe, Takaharu, et al.
Publicado: (2018)

Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D(3)
por: Charoenphandhu, Narattaphol, et al.
Publicado: (2019)

Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro
por: Costa, Jessica L., et al.
Publicado: (2011)

Magnesium vs. machined surfaced titanium - osteoblast and osteoclast differentiation
por: Kwon, Yong-Dae, et al.
Publicado: (2014)

The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer
por: Dushyanthen, Sathana, et al.
Publicado: (2013)

Optimization of the Static Human Osteoblast/Osteoclast Co-culture System
por: Jolly, James Jam, et al.
Publicado: (2018)

4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation
por: Hagiwara, Hiromi, et al.
Publicado: (2018)

Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts
por: Wu, Yan-Bin, et al.
Publicado: (2009)

Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro
por: Yu, Su-Bin, et al.
Publicado: (2018)

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation
por: Sekiguchi, Yuusuke, et al.
Publicado: (2017)

Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis
por: Park, See-Hyoung, et al.
Publicado: (2020)

The Role of miR-21 in Osteoblasts–Osteoclasts Coupling In Vitro
por: Smieszek, Agnieszka, et al.
Publicado: (2020)

Geranylgeraniol Application in Human Osteoblasts and Osteoclasts for Reversal of the Effect of Bisphosphonates
por: Jung, Junho, et al.
Publicado: (2023)

Screening diagnostic markers of osteoporosis based on ferroptosis of osteoblast and osteoclast
por: Cao, Zhihai, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_42cuj8an7frf5jot1msaimmvki