Cargando…

Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling

Adult human cardiomyocytes have an extremely limited proliferative capacity, which poses a great barrier to regenerative medicine and research. Human embryonic stem cells (hESCs) have been proposed as an alternative source to generate large numbers of clinical grade cardiomyocytes (CMs) that can hav...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Ji-Hye, Kim, Min-Seong, Antao, Ainsley Mike, Jo, Won-Jun, Kim, Hyung-Joon, Kim, Su-Jin, Choi, Myeong-Jun, Ramakrishna, Suresh, Kim, Kye-Seong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267745/ https://www.ncbi.nlm.nih.gov/pubmed/34209900 http://dx.doi.org/10.3390/ijms22137015

Ejemplares similares

Corrigendum to “Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice”
por: Park, Youngheon, et al.
Publicado: (2023)

O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells
por: Lee, Hyun Jik, et al.
Publicado: (2019)

Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells
por: Rhie, Byung-Ho, et al.
Publicado: (2021)

The Role of Nkx3.1 in Cancers and Stemness
por: Antao, Ainsley Mike, et al.
Publicado: (2021)

O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson’s Disease Mouse Models
por: Lee, Hyeon Jin, et al.
Publicado: (2022)

Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics
por: Antao, Ainsley Mike, et al.
Publicado: (2020)

Disease modeling and stem cell immunoengineering in regenerative medicine using CRISPR/Cas9 systems
por: Antao, Ainsley Mike, et al.
Publicado: (2020)

Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells
por: Han, Sang Hee, et al.
Publicado: (2015)

USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B
por: Antao, Ainsley Mike, et al.
Publicado: (2021)

Revealing a signaling role of phytosphingosine-1-phosphate in yeast
por: Cowart, L Ashley, et al.
Publicado: (2010)

Cyclic Phytosphingosine-1-Phosphate Primed Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice
por: Park, Youngheon, et al.
Publicado: (2023)

The effect of Phytosphingosine and bioactive glass-ceramics in preventing dental enamel erosion
por: de Araujo, Leticia Campos, et al.
Publicado: (2023)

E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function
por: Tyagi, Apoorvi, et al.
Publicado: (2020)

Phytosphingosine induces systemic acquired resistance through activation of sphingosine kinase
por: Seo, So Yeon, et al.
Publicado: (2021)

Antimicrobial effect of phytosphingosine in acrylic resin
por: Pejon, Luiza Sanchez, et al.
Publicado: (2023)

Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders
por: Das, Soumyadip, et al.
Publicado: (2020)

The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
por: Suresh, Bharathi, et al.
Publicado: (2016)

Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia
por: Sarodaya, Neha, et al.
Publicado: (2020)

Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities?
por: Poondla, Naresh, et al.
Publicado: (2019)

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
por: Agnew, Christopher, et al.
Publicado: (2021)

Phytosphingosine exhibits an anti-epithelial–mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cells
por: Kang, Hye-Min, et al.
Publicado: (2017)

Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal Carcinoma
por: Chandrasekaran, Arun Pandian, et al.
Publicado: (2021)

Development and evaluation of next-generation cardiotoxicity assay based on embryonic stem cell-derived cardiomyocytes
por: Ryu, Bokyeong, et al.
Publicado: (2020)

The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies
por: Sarodaya, Neha, et al.
Publicado: (2020)

Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
por: Rasaei, Roya, et al.
Publicado: (2020)

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling
por: Herhaus, Lina, et al.
Publicado: (2014)

E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination
por: Kaushal, Kamini, et al.
Publicado: (2020)

USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2
por: Chandrasekaran, Arun Pandian, et al.
Publicado: (2021)

Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2
por: Kim, Myung-Jin, et al.
Publicado: (2017)

Estradiol Upregulates the Expression of the TGF-β Receptors ALK5 and BMPR2 during the Gonadal Development of Schizothorax prenanti
por: Yan, Taiming, et al.
Publicado: (2021)

Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression
por: Woo, Jong Kyu, et al.
Publicado: (2018)

Alk3/Alk3b and Smad5 Mediate BMP Signaling during Lymphatic Development in Zebrafish
por: Kim, Jun-Dae, et al.
Publicado: (2014)

Temporal and Spatial Expression Patterns of miR-302 and miR-367 During Early Embryonic Chick Development
por: Jeong, Hoe-Su, et al.
Publicado: (2014)

Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells
por: Nakashima, Keiko, et al.
Publicado: (2022)

Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models
por: Nădăban, Andreea, et al.
Publicado: (2023)

CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis
por: Karapurkar, Janardhan Keshav, et al.
Publicado: (2023)

Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis
por: Jo, Sungsin, et al.
Publicado: (2023)

Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency
por: Lee, Young Jin, et al.
Publicado: (2016)

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids
por: Nagasawa, Tomotaka, et al.
Publicado: (2021)

The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens
por: Glenz, René, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_asf9q5ui92su1i0s2l8u0h0km2