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The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein that interacts with the host cell receptor is the Spike-1 (S1) subunit of the coronavirus. This subunit binds with receptors pr...

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Autores principales: Gudowska-Sawczuk, Monika, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267897/
https://www.ncbi.nlm.nih.gov/pubmed/34202613
http://dx.doi.org/10.3390/jcm10132772
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author Gudowska-Sawczuk, Monika
Mroczko, Barbara
author_facet Gudowska-Sawczuk, Monika
Mroczko, Barbara
author_sort Gudowska-Sawczuk, Monika
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein that interacts with the host cell receptor is the Spike-1 (S1) subunit of the coronavirus. This subunit binds with receptors present on the host cell membrane. It has been identified from several studies that neuropilin-1 (NRP-1) is one of the co-receptors for SARS-CoV-2 entry. Therefore, in this review, we focus on the significance of NRP-1 in SARS-CoV-2 infection. MEDLINE/PubMed database was used for a search of available literature. In the current review, we report that NRP-1 plays many important functions, including angiogenesis, neuronal development, and the regulation of immune responses. Additionally, the presence of this glycoprotein on the host cell membrane significantly augments the infection and spread of SARS-CoV-2. Literature data suggest that NRP-1 facilitates entry of the virus into the central nervous system through the olfactory epithelium of the nasal cavity. Moreover, published findings show that interfering with VEGF-A/NRP-1 using NRP-1 inhibitors may produce an analgesic effect. The review describes an association between NRP-1, SARS-CoV-2 and, inter alia, pathological changes in the retina. Based on the published findings, we suggest that NRP-1 is a very important mediator implicated in, inter alia, neurological manifestations of SARS-CoV-2 infection. Additionally, it appears that the use of NRP-1 inhibitors is a promising therapeutic strategy for the treatment of SARS-CoV-2 infection.
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spelling pubmed-82678972021-07-10 The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review Gudowska-Sawczuk, Monika Mroczko, Barbara J Clin Med Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovered in 2019, is responsible for the global coronavirus disease 19 (COVID-19) pandemic. The main protein that interacts with the host cell receptor is the Spike-1 (S1) subunit of the coronavirus. This subunit binds with receptors present on the host cell membrane. It has been identified from several studies that neuropilin-1 (NRP-1) is one of the co-receptors for SARS-CoV-2 entry. Therefore, in this review, we focus on the significance of NRP-1 in SARS-CoV-2 infection. MEDLINE/PubMed database was used for a search of available literature. In the current review, we report that NRP-1 plays many important functions, including angiogenesis, neuronal development, and the regulation of immune responses. Additionally, the presence of this glycoprotein on the host cell membrane significantly augments the infection and spread of SARS-CoV-2. Literature data suggest that NRP-1 facilitates entry of the virus into the central nervous system through the olfactory epithelium of the nasal cavity. Moreover, published findings show that interfering with VEGF-A/NRP-1 using NRP-1 inhibitors may produce an analgesic effect. The review describes an association between NRP-1, SARS-CoV-2 and, inter alia, pathological changes in the retina. Based on the published findings, we suggest that NRP-1 is a very important mediator implicated in, inter alia, neurological manifestations of SARS-CoV-2 infection. Additionally, it appears that the use of NRP-1 inhibitors is a promising therapeutic strategy for the treatment of SARS-CoV-2 infection. MDPI 2021-06-24 /pmc/articles/PMC8267897/ /pubmed/34202613 http://dx.doi.org/10.3390/jcm10132772 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gudowska-Sawczuk, Monika
Mroczko, Barbara
The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title_full The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title_fullStr The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title_full_unstemmed The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title_short The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: Review
title_sort role of neuropilin-1 (nrp-1) in sars-cov-2 infection: review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267897/
https://www.ncbi.nlm.nih.gov/pubmed/34202613
http://dx.doi.org/10.3390/jcm10132772
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