The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens

Casearlucin A, a diterpenoid obtained from Casearia graveolens, has been reported to possess strong cytotoxic activity. However, the in vivo anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage...

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Autores principales: Li, Ying, Ma, Jun, Song, Ziteng, Zhao, Yinan, Zhang, Han, Li, Yeling, Xu, Jing, Guo, Yuanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267910/
https://www.ncbi.nlm.nih.gov/pubmed/34249737
http://dx.doi.org/10.3389/fonc.2021.688195
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author Li, Ying
Ma, Jun
Song, Ziteng
Zhao, Yinan
Zhang, Han
Li, Yeling
Xu, Jing
Guo, Yuanqiang
author_facet Li, Ying
Ma, Jun
Song, Ziteng
Zhao, Yinan
Zhang, Han
Li, Yeling
Xu, Jing
Guo, Yuanqiang
author_sort Li, Ying
collection PubMed
description Casearlucin A, a diterpenoid obtained from Casearia graveolens, has been reported to possess strong cytotoxic activity. However, the in vivo anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration via regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish in vivo. More importantly, casearlucin A significantly inhibited cell proliferation and migration in an in vivo zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent.
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spelling pubmed-82679102021-07-10 The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens Li, Ying Ma, Jun Song, Ziteng Zhao, Yinan Zhang, Han Li, Yeling Xu, Jing Guo, Yuanqiang Front Oncol Oncology Casearlucin A, a diterpenoid obtained from Casearia graveolens, has been reported to possess strong cytotoxic activity. However, the in vivo anti-tumor effects and the action mechanism of casearlucin A remain poorly understood. Our study revealed that casearlucin A arrested cell cycle at G0/G1 stage and induced cell apoptosis in cell level. Additionally, casearlucin A inhibited HepG2 cell migration via regulating a few of metastasis-related proteins. Furthermore, it inhibited tumor angiogenesis in zebrafish in vivo. More importantly, casearlucin A significantly inhibited cell proliferation and migration in an in vivo zebrafish xenograft model. Collectively, these results are valuable for the further development and application of casearlucin A as an anticancer agent. Frontiers Media S.A. 2021-06-25 /pmc/articles/PMC8267910/ /pubmed/34249737 http://dx.doi.org/10.3389/fonc.2021.688195 Text en Copyright © 2021 Li, Ma, Song, Zhao, Zhang, Li, Xu and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Ying
Ma, Jun
Song, Ziteng
Zhao, Yinan
Zhang, Han
Li, Yeling
Xu, Jing
Guo, Yuanqiang
The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title_full The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title_fullStr The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title_full_unstemmed The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title_short The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens
title_sort antitumor activity and mechanism of a natural diterpenoid from casearia graveolens
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267910/
https://www.ncbi.nlm.nih.gov/pubmed/34249737
http://dx.doi.org/10.3389/fonc.2021.688195
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